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Pathogen-Host Interactions: Antigenic Variation v. Somatic Adaptations

Overview of attention for book
Attention for Chapter 3: Antigenic Variation in Plasmodium falciparum.
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2 tweeters

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72 Mendeley
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Chapter title
Antigenic Variation in Plasmodium falciparum.
Chapter number 3
Book title
Pathogen-Host Interactions: Antigenic Variation v. Somatic Adaptations
Published in
Results and problems in cell differentiation, January 2015
DOI 10.1007/978-3-319-20819-0_3
Pubmed ID
Book ISBNs
978-3-31-920818-3, 978-3-31-920819-0
Authors

Petter, Michaela, Duffy, Michael F, Duffy, Michael F., Michaela Petter, Michael F. Duffy

Abstract

Plasmodium falciparum is the protozoan parasite that causes most malaria-associated morbidity and mortality in humans with over 500,000 deaths annually. The disease symptoms are associated with repeated cycles of invasion and asexual multiplication inside red blood cells of the parasite. Partial, non-sterile immunity to P. falciparum malaria develops only after repeated infections and continuous exposure. The successful evasion of the human immune system relies on the large repertoire of antigenically diverse parasite proteins displayed on the red blood cell surface and on the merozoite membrane where they are exposed to the human immune system. Expression switching of these polymorphic proteins between asexual parasite generations provides an efficient mechanism to adapt to the changing environment in the host and to maintain chronic infection. This chapter discusses antigenic diversity and variation in the malaria parasite and our current understanding of the molecular mechanisms that direct the expression of these proteins.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Kenya 2 3%
India 1 1%
Brazil 1 1%
Argentina 1 1%
Denmark 1 1%
Unknown 66 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 21%
Researcher 13 18%
Student > Master 11 15%
Student > Bachelor 9 13%
Student > Doctoral Student 6 8%
Other 15 21%
Unknown 3 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 38%
Biochemistry, Genetics and Molecular Biology 13 18%
Immunology and Microbiology 10 14%
Medicine and Dentistry 8 11%
Chemistry 2 3%
Other 6 8%
Unknown 6 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2015.
All research outputs
#7,133,918
of 9,686,361 outputs
Outputs from Results and problems in cell differentiation
#78
of 137 outputs
Outputs of similar age
#157,289
of 251,385 outputs
Outputs of similar age from Results and problems in cell differentiation
#2
of 2 outputs
Altmetric has tracked 9,686,361 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 137 research outputs from this source. They receive a mean Attention Score of 1.6. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,385 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.