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Pathogen-Host Interactions: Antigenic Variation v. Somatic Adaptations

Overview of attention for book
Attention for Chapter 12: Diversification of the Primary Antibody Repertoire by AID-Mediated Gene Conversion.
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Chapter title
Diversification of the Primary Antibody Repertoire by AID-Mediated Gene Conversion.
Chapter number 12
Book title
Pathogen-Host Interactions: Antigenic Variation v. Somatic Adaptations
Published in
Results and problems in cell differentiation, January 2015
DOI 10.1007/978-3-319-20819-0_12
Pubmed ID
Book ISBNs
978-3-31-920818-3, 978-3-31-920819-0
Authors

Lanning, Dennis K, Knight, Katherine L, Dennis K. Lanning, Katherine L. Knight

Abstract

Gene conversion, mediated by activation-induced cytidine deaminase (AID), has been found to contribute to generation of the primary antibody repertoire in several vertebrate species. Generation of the primary antibody repertoire by gene conversion of immunoglobulin (Ig) genes occurs primarily in gut-associated lymphoid tissues (GALT) and is best described in chicken and rabbit. Here, we discuss current knowledge of the mechanism of gene conversion as well as the contribution of the microbiota in promoting gene conversion of Ig genes. Finally, we propose that the antibody diversification strategy used in GALT species, such as chicken and rabbit, is conserved in a subset of human and mouse B cells.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 3 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 1 33%
Other 1 33%
Student > Master 1 33%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 67%
Veterinary Science and Veterinary Medicine 1 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2015.
All research outputs
#5,575,156
of 6,535,212 outputs
Outputs from Results and problems in cell differentiation
#44
of 65 outputs
Outputs of similar age
#167,321
of 210,013 outputs
Outputs of similar age from Results and problems in cell differentiation
#2
of 2 outputs
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So far Altmetric has tracked 65 research outputs from this source. They receive a mean Attention Score of 1.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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