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Identification of the molecular switch that regulates access of 5α-DHT to the androgen receptor

Overview of attention for article published in Molecular & Cellular Endocrinology, February 2007
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (65th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

wikipedia
1 Wikipedia page

Citations

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36 Dimensions

Readers on

mendeley
21 Mendeley
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Title
Identification of the molecular switch that regulates access of 5α-DHT to the androgen receptor
Published in
Molecular & Cellular Endocrinology, February 2007
DOI 10.1016/j.mce.2006.12.007
Pubmed ID
Authors

Trevor M. Penning, David R. Bauman, Yi Jin, Tea Lanisik Rizner

Abstract

Pairs of hydroxysteroid dehydrogenases (HSDs) govern ligand access to steroid receptors in target tissues and act as molecular switches. By acting as reductases or oxidases, HSDs convert potent ligands into their cognate inactive metabolites or vice versa. This pre-receptor regulation of steroid hormone action may have profound effects on hormonal response. We have identified the HSDs responsible for regulating ligand access to the androgen receptor (AR) in human prostate. Type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) acts solely as a reductase to convert 5alpha-dihydrotestosterone (DHT), a potent ligand for the AR (K(d)=10(-11)M for the AR), to the inactive androgen 3alpha-androstanediol (K(d)=10(-6)M for the AR); while RoDH like 3alpha-HSD (a short-chain dehydrogenase/reductase (SDR)) acts solely as an oxidase to convert 3alpha-androstanediol back to 5alpha-DHT. Our studies suggest that aldo-keto reductase (AKRs) and SDRs function as reductases and oxidases, respectively, to control ligand access to nuclear receptors.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 24%
Researcher 4 19%
Student > Doctoral Student 3 14%
Student > Bachelor 2 10%
Student > Postgraduate 2 10%
Other 3 14%
Unknown 2 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 43%
Biochemistry, Genetics and Molecular Biology 3 14%
Computer Science 2 10%
Unspecified 1 5%
Medicine and Dentistry 1 5%
Other 0 0%
Unknown 5 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2014.
All research outputs
#3,513,646
of 12,260,757 outputs
Outputs from Molecular & Cellular Endocrinology
#401
of 2,021 outputs
Outputs of similar age
#81,034
of 271,743 outputs
Outputs of similar age from Molecular & Cellular Endocrinology
#9
of 58 outputs
Altmetric has tracked 12,260,757 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,021 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,743 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.