↓ Skip to main content

Protein Reviews

Overview of attention for book
Attention for Chapter 59: The P2X7 Receptor
Altmetric Badge

Mentioned by

2 tweeters

Readers on

60 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
The P2X7 Receptor
Chapter number 59
Book title
Advances in Experimental Medicine and Biology
Published in
Advances in experimental medicine and biology, July 2017
DOI 10.1007/5584_2017_59
Pubmed ID
Book ISBNs
978-9-81-107610-7, 978-9-81-107611-4

Sluyter, Ronald, Ronald Sluyter


The P2X7 receptor is a trimeric ion channel gated by extracellular adenosine 5'-triphosphate. The receptor is present on an increasing number of different cells types including stem, blood, glial, neural, ocular, bone, dental, exocrine, endothelial, muscle, renal and skin cells. The P2X7 receptor induces various downstream events in a cell-specific manner, including inflammatory molecule release, cell proliferation and death, metabolic events, and phagocytosis. As such this receptor plays important roles in heath and disease. Increasing knowledge about the P2X7 receptor has been gained from studies of, but not limited to, protein chemistry including cloning, site-directed mutagenesis, crystal structures and atomic modeling, as well as from studies of primary tissues and transgenic mice. This chapter focuses on the P2X7 receptor itself. This includes the P2RX7 gene and its products including splice and polymorphic variants. This chapter also reviews modulators of P2X7 receptor activation and inhibition, as well as the transcriptional regulation of the P2RX7 gene via its promoter and enhancer regions, and by microRNA and long-coding RNA. Furthermore, this chapter discusses the post-translational modification of the P2X7 receptor by N-linked glycosylation, adenosine 5'-diphosphate ribosylation and palmitoylation. Finally, this chapter reviews interaction partners of the P2X7 receptor, and its cellular localisation and trafficking within cells.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 60 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 14 23%
Student > Master 11 18%
Student > Ph. D. Student 9 15%
Researcher 6 10%
Professor > Associate Professor 2 3%
Other 6 10%
Unknown 12 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 28%
Medicine and Dentistry 7 12%
Agricultural and Biological Sciences 6 10%
Immunology and Microbiology 6 10%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Other 8 13%
Unknown 12 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2018.
All research outputs
of 12,368,793 outputs
Outputs from Advances in experimental medicine and biology
of 3,189 outputs
Outputs of similar age
of 265,009 outputs
Outputs of similar age from Advances in experimental medicine and biology
of 4 outputs
Altmetric has tracked 12,368,793 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,189 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,009 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.