Chapter title |
ATP-Gated P2X3 Receptors Are Specialised Sensors of the Extracellular Environment
|
---|---|
Chapter number | 56 |
Book title |
Protein Reviews
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/5584_2017_56 |
Pubmed ID | |
Book ISBNs |
978-9-81-107610-7, 978-9-81-107611-4
|
Authors |
Elsa Fabbretti, Fabbretti, Elsa |
Abstract |
P2X3 receptors are ion channels expressed by autonomic and sensory nerves and specialised in transducing extracellular ATP signals. Structural data, together with functional and biochemical studies, suggest that conformational changes of P2X3 receptors upon agonist binding influence downstream intracellular molecular mechanisms relevant for neuronal responses. Activity of P2X3 receptors is implicated in pain, itch, asthma, cardiovascular dysfunction and other pathologies. The study of these receptors has therefore a large potential in the field of drug development and interdisciplinary efforts could clarify molecular mechanisms controlling P2X3 receptor function in different physiological or pathological contexts. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 33% |
Other | 2 | 13% |
Student > Master | 2 | 13% |
Professor | 1 | 7% |
Professor > Associate Professor | 1 | 7% |
Other | 0 | 0% |
Unknown | 4 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 2 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Neuroscience | 1 | 7% |
Other | 2 | 13% |
Unknown | 5 | 33% |