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Protein Reviews

Overview of attention for book
Attention for Chapter 98: Structure, Pharmacology and Roles in Physiology of the P2Y 12 Receptor
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (62nd percentile)

Mentioned by

twitter
1 tweeter
wikipedia
1 Wikipedia page

Readers on

mendeley
15 Mendeley
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Chapter title
Structure, Pharmacology and Roles in Physiology of the P2Y 12 Receptor
Chapter number 98
Book title
Protein Reviews
Published in
Advances in experimental medicine and biology, January 2017
DOI 10.1007/5584_2017_98
Pubmed ID
Book ISBNs
978-9-81-107610-7, 978-9-81-107611-4
Authors

Ivar von Kügelgen, von Kügelgen, Ivar

Abstract

P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. The platelet ADP-receptor which has been denominated P2Y12 receptor is an important target in pharmacotherapy. The receptor couples to Gαi2 mediating an inhibition of cyclic AMP accumulation and additional downstream events including the activation of phosphatidylinositol-3-kinase and Rap1b proteins. The nucleoside analogue ticagrelor and active metabolites of the thienopyridine compounds ticlopidine, clopidogrel and prasugrel block P2Y12 receptors and, thereby, inhibit ADP-induced platelet aggregation. These drugs are used for the prevention and therapy of cardiovascular events such as acute coronary syndromes or stroke. The recently published three-dimensional crystal structures of the human P2Y12 receptor in complex with agonists and antagonists will facilitate the development of novel therapeutic agents with reduced adverse effects. P2Y12 receptors are also expressed on vascular smooth muscle cells and may be involved in the pathophysiology of atherogenesis. P2Y12 receptors on microglial cells operate as sensors for adenine nucleotides released during brain injury. A recent study indicated the involvement of microglial P2Y12 receptors in the activity-dependent neuronal plasticity. Interestingly, there is evidence for changes in P2Y12 receptor expression in CNS pathologies including Alzheimer's diseases and multiple sclerosis. P2Y12 receptors may also be involved in systemic immune modulating responses and the susceptibility to develop bronchial asthma.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 13%
Student > Master 2 13%
Student > Postgraduate 2 13%
Student > Bachelor 2 13%
Lecturer 1 7%
Other 1 7%
Unknown 5 33%
Readers by discipline Count As %
Medicine and Dentistry 5 33%
Agricultural and Biological Sciences 2 13%
Biochemistry, Genetics and Molecular Biology 1 7%
Immunology and Microbiology 1 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Other 0 0%
Unknown 5 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 November 2018.
All research outputs
#4,036,949
of 13,887,828 outputs
Outputs from Advances in experimental medicine and biology
#597
of 3,332 outputs
Outputs of similar age
#101,186
of 276,568 outputs
Outputs of similar age from Advances in experimental medicine and biology
#1
of 1 outputs
Altmetric has tracked 13,887,828 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 3,332 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,568 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them