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Protein Reviews

Overview of attention for book
Attention for Chapter 55: P2X Receptor Activation
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Chapter title
P2X Receptor Activation
Chapter number 55
Book title
Protein Reviews
Published in
Advances in experimental medicine and biology, January 2017
DOI 10.1007/5584_2017_55
Pubmed ID
Book ISBNs
978-9-81-107610-7, 978-9-81-107611-4
Authors

Toshimitsu Kawate

Abstract

Extracellular ATP-gated P2X receptors are trimeric non-selective cation channels important for many physiological events including immune response and neural transmission. These receptors belong to a unique class of ligand-gated ion channels composed of only six transmembrane helices and a relatively small extracellular domain that harbors three ATP-binding pockets. The crystal structures of P2X receptors, including the recent P2X3 structures representing three different stages of the gating cycle, have provided a compelling structural foundation for understanding how this class of ligand-gated ion channels function. These structures, in combination with numerous functional studies ranging from classic mutagenesis and electrophysiology to modern optogenetic pharmacology, have uncovered unique molecular mechanisms of P2X receptor function. This review article summarizes the current knowledge in P2X receptor activation, especially focusing on the mechanisms underlying ATP-binding, conformational changes in the extracellular domain, and channel gating and desensitization.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 19%
Researcher 4 19%
Student > Master 3 14%
Lecturer > Senior Lecturer 2 10%
Student > Bachelor 2 10%
Other 4 19%
Unknown 2 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 24%
Biochemistry, Genetics and Molecular Biology 3 14%
Pharmacology, Toxicology and Pharmaceutical Science 3 14%
Chemistry 3 14%
Neuroscience 2 10%
Other 2 10%
Unknown 3 14%