Chapter title |
P2Y 11 Receptors: Properties, Distribution and Functions
|
---|---|
Chapter number | 89 |
Book title |
Protein Reviews
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/5584_2017_89 |
Pubmed ID | |
Book ISBNs |
978-9-81-107610-7, 978-9-81-107611-4
|
Authors |
Charles Kennedy, Kennedy, Charles |
Abstract |
The P2Y11 receptor is a G protein-coupled receptor that is stimulated by endogenous purine nucleotides, particularly ATP. Amongst P2Y receptors it has several unique properties; (1) it is the only human P2Y receptor gene that contains an intron in the coding sequence; (2) the gene does not appear to be present in the rodent genome; (3) it couples to stimulation of both phospholipase C and adenylyl cyclase. Its absence in mice and rats, along with a limited range of selective pharmacological tools, has hampered the development of our knowledge and understanding of its properties and functions. Nonetheless, through a combination of careful use of the available tools, suppression of receptor expression using siRNA and genetic screening for SNPs, possible functions of native P2Y11 receptors have been identified in a variety of human cells and tissues. Many are in blood cells involved in inflammatory responses, consistent with extracellular ATP being a damage-associated signalling molecule in the immune system. Thus proposed potential therapeutic applications relate, in the main, to modulation of acute and chronic inflammatory responses. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 27% |
Student > Ph. D. Student | 3 | 20% |
Student > Doctoral Student | 2 | 13% |
Student > Master | 1 | 7% |
Student > Postgraduate | 1 | 7% |
Other | 0 | 0% |
Unknown | 4 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 33% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 13% |
Neuroscience | 2 | 13% |
Agricultural and Biological Sciences | 1 | 7% |
Economics, Econometrics and Finance | 1 | 7% |
Other | 1 | 7% |
Unknown | 3 | 20% |