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Protein Reviews

Overview of attention for book
Attention for Chapter 90: P2Y 2 Receptor Functions in Cancer: A Perspective in the Context of Colorectal Cancer
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8 Mendeley
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Chapter title
P2Y 2 Receptor Functions in Cancer: A Perspective in the Context of Colorectal Cancer
Chapter number 90
Book title
Protein Reviews
Published in
Advances in experimental medicine and biology, January 2017
DOI 10.1007/5584_2017_90
Pubmed ID
Book ISBNs
978-9-81-107610-7, 978-9-81-107611-4

Fernand-Pierre Gendron, Morgane Placet, Guillaume Arguin


Purinergic signaling has recently emerged as a network of signaling molecules, enzymes and receptors that coordinates the action and behavior of cancerous cells. Extracellular adenosine 5' triphosphate activates a plethora of P2 nucleotide receptors that can putatively modulate cancer cell proliferation, survival and dissemination. In this context, the G protein-coupled P2Y2 receptor was identified as one of the entities coordinating the cellular and molecular events that characterize cancerous cells. In this chapter, we will look at the contribution of the P2Y2 receptor in cancer outcomes and use this information to demonstrate that the P2Y2 receptor represents a drug target of interest in the setting of colorectal cancer, for which the role and function of this receptor is poorly defined. More particularly, we will review how the P2Y2 receptor modulates cancer cell proliferation and survival, while promoting cell dissemination and formation of metastases. Finally, we will investigate how the P2Y2 receptor can contribute to the detrimental development of drug resistance that is often observed in cancerous cells.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 38%
Student > Doctoral Student 2 25%
Researcher 1 13%
Unknown 2 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 38%
Pharmacology, Toxicology and Pharmaceutical Science 1 13%
Agricultural and Biological Sciences 1 13%
Immunology and Microbiology 1 13%
Unknown 2 25%