Chapter title |
P2Y 2 Receptor Functions in Cancer: A Perspective in the Context of Colorectal Cancer
|
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Chapter number | 90 |
Book title |
Protein Reviews
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/5584_2017_90 |
Pubmed ID | |
Book ISBNs |
978-9-81-107610-7, 978-9-81-107611-4
|
Authors |
Fernand-Pierre Gendron, Morgane Placet, Guillaume Arguin, Gendron, Fernand-Pierre, Placet, Morgane, Arguin, Guillaume |
Abstract |
Purinergic signaling has recently emerged as a network of signaling molecules, enzymes and receptors that coordinates the action and behavior of cancerous cells. Extracellular adenosine 5' triphosphate activates a plethora of P2 nucleotide receptors that can putatively modulate cancer cell proliferation, survival and dissemination. In this context, the G protein-coupled P2Y2 receptor was identified as one of the entities coordinating the cellular and molecular events that characterize cancerous cells. In this chapter, we will look at the contribution of the P2Y2 receptor in cancer outcomes and use this information to demonstrate that the P2Y2 receptor represents a drug target of interest in the setting of colorectal cancer, for which the role and function of this receptor is poorly defined. More particularly, we will review how the P2Y2 receptor modulates cancer cell proliferation and survival, while promoting cell dissemination and formation of metastases. Finally, we will investigate how the P2Y2 receptor can contribute to the detrimental development of drug resistance that is often observed in cancerous cells. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 36% |
Researcher | 2 | 18% |
Student > Doctoral Student | 2 | 18% |
Unknown | 3 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 45% |
Agricultural and Biological Sciences | 1 | 9% |
Immunology and Microbiology | 1 | 9% |
Social Sciences | 1 | 9% |
Unknown | 3 | 27% |