Chapter title |
The role of hypoxia-inducible factors in oxygen sensing by the carotid body.
|
---|---|
Chapter number | 1 |
Book title |
Arterial Chemoreception
|
Published in |
Advances in experimental medicine and biology, January 2012
|
DOI | 10.1007/978-94-007-4584-1_1 |
Pubmed ID | |
Book ISBNs |
978-9-40-074583-4, 978-9-40-074584-1
|
Authors |
Semenza, Gregg L, Prabhakar, Nanduri R, Gregg L. Semenza, Nanduri R. Prabhakar, Semenza, Gregg L., Prabhakar, Nanduri R. |
Abstract |
Chronic intermittent hypoxia (IH) associated with sleep-disordered breathing is an important cause of hypertension, which results from carotid body-mediated activation of the sympathetic nervous system. IH triggers increased levels of reactive oxygen species (ROS) in the carotid body, which induce increased synthesis and stability of hypoxia-inducible factor 1α (HIF-1α) and calpain-dependent degradation of HIF-2α. HIF-1 activates transcription of the Nox2 gene, encoding NADPH oxidase 2, which generates superoxide. Loss of HIF-2 activity leads to decreased transcription of the Sod2 gene, encoding manganese superoxide dismutase, which converts superoxide to hydrogen peroxide. Thus, IH disrupts the balance between HIF-1-dependent pro-oxidant and HIF-2-dependent anti-oxidant activities, and this loss of redox homeostasis underlies the pathogenesis of autonomic morbidities associated with IH. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 2% |
Spain | 1 | 2% |
Czechia | 1 | 2% |
Unknown | 38 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 27% |
Researcher | 6 | 15% |
Professor > Associate Professor | 5 | 12% |
Professor | 5 | 12% |
Student > Master | 2 | 5% |
Other | 4 | 10% |
Unknown | 8 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 32% |
Biochemistry, Genetics and Molecular Biology | 5 | 12% |
Agricultural and Biological Sciences | 5 | 12% |
Neuroscience | 3 | 7% |
Chemistry | 2 | 5% |
Other | 3 | 7% |
Unknown | 10 | 24% |