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Pulmonary Care and Clinical Medicine

Overview of attention for book
Attention for Chapter 27: Influence of Vitamin D and Cotinine on T-Regulatory Cells and Asthma Severity in Children
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Chapter title
Influence of Vitamin D and Cotinine on T-Regulatory Cells and Asthma Severity in Children
Chapter number 27
Book title
Advances in Experimental Medicine and Biology
Published in
Advances in experimental medicine and biology, July 2017
DOI 10.1007/5584_2017_27
Pubmed ID
Book ISBNs
978-3-31-965468-3, 978-3-31-965469-0
Authors

Kalicki, Bolesław, Wawrzyniak, Agata, Lipińska-Opałka, Agnieszka, Lewicki, Sławomir, Zdanowski, Robert, Bolesław Kalicki, Agata Wawrzyniak, Agnieszka Lipińska-Opałka, Sławomir Lewicki, Robert Zdanowski

Abstract

Asthma is a common chronic respiratory diseases in children. Understanding the immune mechanisms of epigenetic factors may contribute to a better control of asthma. This study seeks to determine the effects of serum vitamin D and urine cotinine on asthma severity and on T regulatory cells (Tregs) and other immune-related factors such as CD3, CD4, CD8, CD19, CD16/56, and anti-CD3 HLA-DR3. The study involved 34 children with asthma. Disease severity was assessed with the Asthma Control Test, spirometry, and the fractional exhaled nitric oxide (FeNO). The control group consisted of 18 healthy children. We found a significantly lower proportion of Tregs in the serum of asthmatic children compared with the control group (p < 0.002). There were no significant differences in the other immunological factors investigated. Nor was there any appreciable association between vitamin D or cotinine and the course of asthma, FeNO, Tregs, and the other immune factors. However, the percentage of Tregs was positively associated with the level of FeNO (p < 0.02). In conclusion, the study shows a role of T regulatory cells in the pathogenesis of asthma in children, but fails to show any influence of serum vitamin D or urine cotinine on disease course.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 15%
Student > Master 2 15%
Student > Bachelor 2 15%
Student > Doctoral Student 1 8%
Student > Ph. D. Student 1 8%
Other 1 8%
Unknown 4 31%
Readers by discipline Count As %
Medicine and Dentistry 6 46%
Nursing and Health Professions 1 8%
Immunology and Microbiology 1 8%
Agricultural and Biological Sciences 1 8%
Unknown 4 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2017.
All research outputs
#15,470,944
of 22,990,068 outputs
Outputs from Advances in experimental medicine and biology
#2,514
of 4,960 outputs
Outputs of similar age
#197,805
of 314,579 outputs
Outputs of similar age from Advances in experimental medicine and biology
#35
of 73 outputs
Altmetric has tracked 22,990,068 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,960 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,579 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.