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Ligand-Macromolecular Interactions in Drug Discovery

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Table of Contents

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    Book Overview
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    Chapter 1 An Historical Overview of Drug Discovery
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    Chapter 2 Ligand Macromolecule Interactions: Theoretical Principles of Molecular Recognition
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    Chapter 3 X-ray crystallography in drug discovery.
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    Chapter 4 Virtual Screening of Compound Libraries
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    Chapter 5 Combinatorial Chemistry and the Synthesis of Compound Libraries
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    Chapter 6 Ligand-Based Nuclear Magnetic Resonance Screening Techniques
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    Chapter 7 Isothermal Titration Calorimetry and Differential Scanning Calorimetry
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    Chapter 8 Adaptive Combinatorial Design of Focused Compound Libraries
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    Chapter 9 Chemical Microarrays: A New Tool for Discovery Enzyme Inhibitors
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    Chapter 10 Fluorescence Polarization and Time-Resolved Fluorescence Resonance Energy Transfer Techniques for PI3K Assays
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    Chapter 11 Small Molecule Protein Interaction Profiling with Functional Protein Microarrays
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    Chapter 12 Capillary Electrophoresis in Drug Discovery
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    Chapter 13 SPR in Drug Discovery: Searching Bioactive Compounds in Plant Extracts
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    Chapter 14 Application of Frontal Affinity Chromatography with Mass Spectrometry (FAC–MS) for Stereospecific Ligand–Macromolecule Interaction, Detection and Screening
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    Chapter 15 GPC Spin Column HPLC–ESI-MS Methods for Screening Drugs Noncovalently Bound to Proteins
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    Chapter 16 A scintillation proximity assay for fatty acid amide hydrolase compatible with inhibitor screening.
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    Chapter 17 A Natural Products Approach to Drug Discovery: Probing Modes of Action of Antitumor Agents by Genome-Scale cDNA Library Screening
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    Chapter 18 Ligand–Macromolecule Interactions in Live Cells by Fluorescence Correlation Spectroscopy
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