Chapter title |
The Pulmonary Vascular Barrier: Insights into Structure, Function, and Regulatory Mechanisms
|
---|---|
Chapter number | 3 |
Book title |
Molecular and Functional Insights Into the Pulmonary Vasculature
|
Published in |
Advances in anatomy embryology and cell biology, January 2018
|
DOI | 10.1007/978-3-319-68483-3_3 |
Pubmed ID | |
Book ISBNs |
978-3-31-968482-6, 978-3-31-968483-3
|
Authors |
Kaushik Parthasarathi, Parthasarathi, Kaushik |
Abstract |
Pulmonary blood vessels act as a well-regulated barrier to the flux of fluid and solutes between the lumen and the air space. Perturbation of the barrier function results in excessive fluid leak into the interstitium and alveoli, and impairs gas exchange. Recent studies provide deeper insight into the precise control mechanisms involved in the regulation of the barrier. This chapter will highlight these mechanisms and discuss the current understanding on the fluid and solute transport pathways across the vascular endothelial layer. In addition, the chapter summarizes the contributions of extra-endothelial structures such as pericytes and glycocalyx in regulating fluid flux across pulmonary vessels. The chapter concludes with an analysis on the impact of pulmonary endothelial heterogeneity and experimental models on current interpretations of barrier function and regulatory mechanisms. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Postgraduate | 3 | 20% |
Student > Doctoral Student | 2 | 13% |
Other | 1 | 7% |
Unspecified | 1 | 7% |
Student > Master | 1 | 7% |
Other | 3 | 20% |
Unknown | 4 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 40% |
Nursing and Health Professions | 2 | 13% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Veterinary Science and Veterinary Medicine | 1 | 7% |
Unspecified | 1 | 7% |
Other | 1 | 7% |
Unknown | 3 | 20% |