Chapter title |
Virus infection and human cancer: an overview.
|
---|---|
Chapter number | 1 |
Book title |
Viruses and Human Cancer
|
Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, January 2014
|
DOI | 10.1007/978-3-642-38965-8_1 |
Pubmed ID | |
Book ISBNs |
978-3-64-238964-1, 978-3-64-238965-8
|
Authors |
Schiller JT, Lowy DR, John T. Schiller, Douglas R. Lowy, Schiller, John T., Lowy, Douglas R. |
Abstract |
It is now estimated that approximately 10 % of worldwide cancers are attributable to viral infection, with the vast majority (>85 %) occurring in the developing world. Oncogenic viruses include various classes of DNA and RNA viruses and induce cancer by a variety of mechanisms. A unifying theme is that cancer develops in a minority of infected individuals and only after chronic infection of many years duration. The viruses associated with the greatest number of cancer cases are the human papillomaviruses (HPVs), which cause cervical cancer and several other epithelial malignancies, and the hepatitis viruses HBV and HCV, which are responsible for the majority of hepatocellular cancer. Other oncoviruses include Epstein-Barr virus (EBV), Kaposi's sarcoma-associated herpes virus (KSHV), human T-cell leukemia virus (HTLV-I), and Merkel cell polyomavirus (MCPyV). Identification of the infectious cause has led to several interventions that may reduce the risk of developing these tumors. These include preventive vaccines against HBV and HPV, HPV-based testing for cervical cancer screening, anti-virals for the treatment of chronic HBV and HCV infection, and screening the blood supply for the presence of HBV and HCV. Successful efforts to identify additional oncogenic viruses in human cancer may lead to further insight into etiology and pathogenesis as well as to new approaches for therapeutic and prophylactic intervention. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 22% |
United Kingdom | 1 | 11% |
Serbia | 1 | 11% |
Canada | 1 | 11% |
Unknown | 4 | 44% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 67% |
Scientists | 2 | 22% |
Science communicators (journalists, bloggers, editors) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 1% |
Unknown | 91 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 20% |
Student > Bachelor | 11 | 12% |
Student > Master | 9 | 10% |
Researcher | 5 | 5% |
Student > Doctoral Student | 4 | 4% |
Other | 15 | 16% |
Unknown | 30 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 22 | 24% |
Biochemistry, Genetics and Molecular Biology | 16 | 17% |
Agricultural and Biological Sciences | 10 | 11% |
Immunology and Microbiology | 3 | 3% |
Engineering | 2 | 2% |
Other | 7 | 8% |
Unknown | 32 | 35% |