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Mendeley readers
| Chapter title |
Controlled Delivery of Sonic Hedgehog with a Heparin-Based Coacervate
|
|---|---|
| Chapter number | 1 |
| Book title |
Hedgehog Signaling Protocols
|
| Published in |
Methods in molecular biology, January 2015
|
| DOI | 10.1007/978-1-4939-2772-2_1 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-2771-5, 978-1-4939-2772-2
|
| Authors |
Johnson, Noah Ray, Wang, Yadong, Noah Ray Johnson, Yadong Wang |
| Abstract |
Here we describe the preparation of a delivery vehicle for controlled release of Sonic hedgehog (Shh). The vehicle contains a synthetic polycation and heparin which interact by polyvalent charge attraction and rapidly self-assemble into liquid coacervate droplets. The coacervate loads Shh with high efficiency, protects its bioactivity, and provides sustained and localized release at the site of application. Shh coacervate may be injected directly or coated onto a polymeric scaffold for tissue engineering approaches, as described here. |
Mendeley readers
The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 4 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 1 | 25% |
| Student > Bachelor | 1 | 25% |
| Student > Master | 1 | 25% |
| Unknown | 1 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 1 | 25% |
| Materials Science | 1 | 25% |
| Engineering | 1 | 25% |
| Unknown | 1 | 25% |