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Target Identification and Validation in Drug Discovery

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Cover of 'Target Identification and Validation in Drug Discovery'

Table of Contents

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    Book Overview
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    Chapter 1 The Path to Oncology Drug Target Validation: An Industry Perspective
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    Chapter 2 Identification of Aptamers as Specific Binders and Modulators of Cell-Surface Receptor Activity
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    Chapter 3 The Design and Structure–Functional Properties of DNA-Based Immunomodulatory Sequences
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    Chapter 4 siRNA Design Principles and Off-Target Effects
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    Chapter 5 Western Blot Evaluation of siRNA Delivery by pH-Responsive Peptides
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    Chapter 6 High-Throughput RNAi Screening for the Identification of Novel Targets
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    Chapter 7 Integration of RNAi and Small Molecule Screens to Identify Targets for Drug Development
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    Chapter 8 CellProfiler and KNIME: Open Source Tools for High Content Screening.
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    Chapter 9 PARP inhibition as a prototype for synthetic lethal screens.
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    Chapter 10 Structure-Based Target Druggability Assessment
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    Chapter 11 Validating Pharmacological Disruption of Protein–Protein Interactions by Acceptor Photobleaching FRET Imaging
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    Chapter 12 Systematic Analysis of Complex Signal Transduction Pathways Using Protein Fragment Complementation Assays
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    Chapter 13 Reverse Phase Protein Microarrays and Their Utility in Drug Development
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    Chapter 14 A Cell Culture System That Mimics Chronic Lymphocytic Leukemia Cells Microenvironment for Drug Screening and Characterization
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    Chapter 15 Two-Dimensional vs. Three-Dimensional In Vitro Tumor Migration and Invasion Assays
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    Chapter 16 Tumor Spheroid-Based Migration Assays for Evaluation of Therapeutic Agents
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    Chapter 17 The Neurosphere Assay Applied to Neural Stem Cells and Cancer Stem Cells
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    Chapter 18 Genetically engineered animal models for in vivo target identification and validation in oncology.
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    Chapter 19 Target Validation in Mice by Constitutive and Conditional RNAi
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    Chapter 20 In Vivo Target Validation by Inducible RNAi in Human Xenograft Mouse Models
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    Chapter 21 Bright-Field In Situ Hybridization Methods to Discover Gene Amplifications and Rearrangements in Clinical Samples
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    Chapter 22 Combined MicroRNA In Situ Hybridization and Immunohistochemical Detection of Protein Markers
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Target Identification and Validation in Drug Discovery
Published by
Humana Press, February 2013
DOI 10.1007/978-1-62703-311-4
978-1-62703-310-7, 978-1-62703-311-4

Moll, Jurgen, Colombo, Riccardo

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The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 175 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 2 1%
Canada 2 1%
France 1 <1%
Netherlands 1 <1%
India 1 <1%
Malaysia 1 <1%
Portugal 1 <1%
United States 1 <1%
Unknown 165 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 48 27%
Researcher 40 23%
Student > Bachelor 23 13%
Student > Master 15 9%
Other 9 5%
Other 26 15%
Unknown 14 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 72 41%
Biochemistry, Genetics and Molecular Biology 35 20%
Chemistry 12 7%
Medicine and Dentistry 12 7%
Engineering 9 5%
Other 20 11%
Unknown 15 9%