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Target Identification and Validation in Drug Discovery

Overview of attention for book
Cover of 'Target Identification and Validation in Drug Discovery'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 The Path to Oncology Drug Target Validation: An Industry Perspective
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    Chapter 2 Identification of Aptamers as Specific Binders and Modulators of Cell-Surface Receptor Activity
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    Chapter 3 The Design and Structure–Functional Properties of DNA-Based Immunomodulatory Sequences
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    Chapter 4 siRNA Design Principles and Off-Target Effects
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    Chapter 5 Western Blot Evaluation of siRNA Delivery by pH-Responsive Peptides
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    Chapter 6 High-Throughput RNAi Screening for the Identification of Novel Targets
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    Chapter 7 Integration of RNAi and Small Molecule Screens to Identify Targets for Drug Development
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    Chapter 8 CellProfiler and KNIME: Open Source Tools for High Content Screening.
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    Chapter 9 PARP inhibition as a prototype for synthetic lethal screens.
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    Chapter 10 Structure-Based Target Druggability Assessment
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    Chapter 11 Validating Pharmacological Disruption of Protein–Protein Interactions by Acceptor Photobleaching FRET Imaging
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    Chapter 12 Systematic Analysis of Complex Signal Transduction Pathways Using Protein Fragment Complementation Assays
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    Chapter 13 Reverse Phase Protein Microarrays and Their Utility in Drug Development
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    Chapter 14 A Cell Culture System That Mimics Chronic Lymphocytic Leukemia Cells Microenvironment for Drug Screening and Characterization
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    Chapter 15 Two-Dimensional vs. Three-Dimensional In Vitro Tumor Migration and Invasion Assays
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    Chapter 16 Tumor Spheroid-Based Migration Assays for Evaluation of Therapeutic Agents
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    Chapter 17 The Neurosphere Assay Applied to Neural Stem Cells and Cancer Stem Cells
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    Chapter 18 Genetically engineered animal models for in vivo target identification and validation in oncology.
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    Chapter 19 Target Validation in Mice by Constitutive and Conditional RNAi
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    Chapter 20 In Vivo Target Validation by Inducible RNAi in Human Xenograft Mouse Models
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    Chapter 21 Bright-Field In Situ Hybridization Methods to Discover Gene Amplifications and Rearrangements in Clinical Samples
  23. Altmetric Badge
    Chapter 22 Combined MicroRNA In Situ Hybridization and Immunohistochemical Detection of Protein Markers
Attention for Chapter 20: In Vivo Target Validation by Inducible RNAi in Human Xenograft Mouse Models
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About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

Mentioned by

patent
1 patent

Citations

dimensions_citation
14 Dimensions

Readers on

mendeley
8 Mendeley
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Chapter title
In Vivo Target Validation by Inducible RNAi in Human Xenograft Mouse Models
Chapter number 20
Book title
Target Identification and Validation in Drug Discovery
Published in
Methods in molecular biology, January 2013
DOI 10.1007/978-1-62703-311-4_20
Pubmed ID
Book ISBNs
978-1-62703-310-7, 978-1-62703-311-4
Authors

Marco Mazzoletti, Gemma Texidó, Mazzoletti, Marco, Texidó, Gemma

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 38%
Researcher 2 25%
Student > Bachelor 1 13%
Student > Doctoral Student 1 13%
Unknown 1 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 25%
Biochemistry, Genetics and Molecular Biology 2 25%
Pharmacology, Toxicology and Pharmaceutical Science 1 13%
Neuroscience 1 13%
Chemistry 1 13%
Other 0 0%
Unknown 1 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2021.
All research outputs
#7,554,540
of 23,045,021 outputs
Outputs from Methods in molecular biology
#2,342
of 13,194 outputs
Outputs of similar age
#84,955
of 282,292 outputs
Outputs of similar age from Methods in molecular biology
#89
of 340 outputs
Altmetric has tracked 23,045,021 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,194 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,292 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 340 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.