↓ Skip to main content

Target Identification and Validation in Drug Discovery

Overview of attention for book
Cover of 'Target Identification and Validation in Drug Discovery'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 The Path to Oncology Drug Target Validation: An Industry Perspective
  3. Altmetric Badge
    Chapter 2 Identification of Aptamers as Specific Binders and Modulators of Cell-Surface Receptor Activity
  4. Altmetric Badge
    Chapter 3 The Design and Structure–Functional Properties of DNA-Based Immunomodulatory Sequences
  5. Altmetric Badge
    Chapter 4 siRNA Design Principles and Off-Target Effects
  6. Altmetric Badge
    Chapter 5 Western Blot Evaluation of siRNA Delivery by pH-Responsive Peptides
  7. Altmetric Badge
    Chapter 6 High-Throughput RNAi Screening for the Identification of Novel Targets
  8. Altmetric Badge
    Chapter 7 Integration of RNAi and Small Molecule Screens to Identify Targets for Drug Development
  9. Altmetric Badge
    Chapter 8 CellProfiler and KNIME: Open Source Tools for High Content Screening.
  10. Altmetric Badge
    Chapter 9 PARP inhibition as a prototype for synthetic lethal screens.
  11. Altmetric Badge
    Chapter 10 Structure-Based Target Druggability Assessment
  12. Altmetric Badge
    Chapter 11 Validating Pharmacological Disruption of Protein–Protein Interactions by Acceptor Photobleaching FRET Imaging
  13. Altmetric Badge
    Chapter 12 Systematic Analysis of Complex Signal Transduction Pathways Using Protein Fragment Complementation Assays
  14. Altmetric Badge
    Chapter 13 Reverse Phase Protein Microarrays and Their Utility in Drug Development
  15. Altmetric Badge
    Chapter 14 A Cell Culture System That Mimics Chronic Lymphocytic Leukemia Cells Microenvironment for Drug Screening and Characterization
  16. Altmetric Badge
    Chapter 15 Two-Dimensional vs. Three-Dimensional In Vitro Tumor Migration and Invasion Assays
  17. Altmetric Badge
    Chapter 16 Tumor Spheroid-Based Migration Assays for Evaluation of Therapeutic Agents
  18. Altmetric Badge
    Chapter 17 The Neurosphere Assay Applied to Neural Stem Cells and Cancer Stem Cells
  19. Altmetric Badge
    Chapter 18 Genetically engineered animal models for in vivo target identification and validation in oncology.
  20. Altmetric Badge
    Chapter 19 Target Validation in Mice by Constitutive and Conditional RNAi
  21. Altmetric Badge
    Chapter 20 In Vivo Target Validation by Inducible RNAi in Human Xenograft Mouse Models
  22. Altmetric Badge
    Chapter 21 Bright-Field In Situ Hybridization Methods to Discover Gene Amplifications and Rearrangements in Clinical Samples
  23. Altmetric Badge
    Chapter 22 Combined MicroRNA In Situ Hybridization and Immunohistochemical Detection of Protein Markers
Attention for Chapter 5: Western Blot Evaluation of siRNA Delivery by pH-Responsive Peptides
Altmetric Badge

Citations

dimensions_citation
14 Dimensions

Readers on

mendeley
33 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
Western Blot Evaluation of siRNA Delivery by pH-Responsive Peptides
Chapter number 5
Book title
Target Identification and Validation in Drug Discovery
Published in
Methods in molecular biology, January 2013
DOI 10.1007/978-1-62703-311-4_5
Pubmed ID
Book ISBNs
978-1-62703-310-7, 978-1-62703-311-4
Authors

Wanling Liang, A. James Mason, Jenny K. W. Lam, Liang, Wanling, Mason, A. James, Lam, Jenny K. W.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 30%
Student > Ph. D. Student 9 27%
Researcher 4 12%
Student > Doctoral Student 3 9%
Student > Master 1 3%
Other 1 3%
Unknown 5 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 27%
Agricultural and Biological Sciences 5 15%
Pharmacology, Toxicology and Pharmaceutical Science 3 9%
Chemistry 3 9%
Medicine and Dentistry 3 9%
Other 4 12%
Unknown 6 18%