| Chapter title |
Quantification of Scleral Biomechanics and Collagen Fiber Alignment
|
|---|---|
| Chapter number | 13 |
| Book title |
Glaucoma
|
| Published in |
Methods in molecular biology, January 2018
|
| DOI | 10.1007/978-1-4939-7407-8_13 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-7406-1, 978-1-4939-7407-8
|
| Authors |
Ian C. Campbell, Joseph M. Sherwood, Darryl R. Overby, Bailey G. Hannon, A. Thomas Read, Julia Raykin, C. Ross Ethier, Campbell, Ian C., Sherwood, Joseph M., Overby, Darryl R., Hannon, Bailey G., Read, A. Thomas, Raykin, Julia, Ethier, C. Ross |
| Abstract |
The stiffness of the sclera is important in several ocular disorders, and there is hence a need to quantify the biomechanical properties of this tissue. Here, we present two methods for measuring the stiffness of scleral ocular tissues: ocular compliance testing and digital image correlation strain mapping. In tandem with these approaches, we provide two methods to spatially quantify the anisotropic alignment of collagen fibers making up the sclera, using second harmonic generation microscopy and small-angle light scattering. Together, these approaches allow specimen-specific measurement of tissue stiffness and collagen alignment, which are key factors in determining how the eye responds to mechanical loads. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 17 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 2 | 12% |
| Lecturer | 2 | 12% |
| Student > Bachelor | 2 | 12% |
| Professor | 2 | 12% |
| Student > Master | 2 | 12% |
| Other | 5 | 29% |
| Unknown | 2 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 4 | 24% |
| Medicine and Dentistry | 4 | 24% |
| Nursing and Health Professions | 1 | 6% |
| Unknown | 8 | 47% |