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Glaucoma

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Cover of 'Glaucoma'

Table of Contents

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    Book Overview
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    Chapter 1 Use of Animal Models and Techniques in Glaucoma Research: Introduction
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    Chapter 2 Hypertonic Saline Injection Model of Experimental Glaucoma in Rats
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    Chapter 3 The Microbead Occlusion Model of Ocular Hypertension in Mice
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    Chapter 4 Ocular Hypertension/Glaucoma in Minipigs: Episcleral Veins Cauterization and Microbead Occlusion Methods
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    Chapter 5 Noninvasive Intraocular Pressure Measurement in Animals Models of Glaucoma
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    Chapter 6 High-Throughput Binocular Pattern Electroretinograms in the Mouse
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    Chapter 7 Visual Evoked Potentials in Glaucoma and Alzheimer’s Disease
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    Chapter 8 Investigation of the Functional Retinal Output Using Microelectrode Arrays
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    Chapter 9 Quantitative Proteomic Analysis of Human Aqueous Humor Using iTRAQ 4plex Labeling
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    Chapter 10 Shotgun Sphingolipid Analysis of Human Aqueous Humor
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    Chapter 11 Assessment of Aqueous Humor Dynamics in the Rodent by Constant Flow Infusion
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    Chapter 12 Methods for Analyzing Endoplasmic Reticulum Stress in the Trabecular Meshwork of Glaucoma Models
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    Chapter 13 Quantification of Scleral Biomechanics and Collagen Fiber Alignment
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    Chapter 14 Biolistic Labeling of Retinal Ganglion Cells
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    Chapter 15 Anterograde Tract Tracing for Assaying Axonopathy and Transport Deficits in Glaucoma
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    Chapter 16 In Vitro and In Vivo Methods for Studying Retinal Ganglion Cell Survival and Optic Nerve Regeneration
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    Chapter 17 3D Histomorphometric Reconstruction and Quantification of the Optic Nerve Head Connective Tissues
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    Chapter 18 Visualizing Astrocytes of the Optic Nerve
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    Chapter 19 Investigation of MicroRNA Expression in Experimental Glaucoma
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    Chapter 20 Utilizing RNA-Seq to Identify Differentially Expressed Genes in Glaucoma Model Tissues, Such as the Rodent Optic Nerve Head
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    Chapter 21 Single-Cell Dissociation and Characterization in the Murine Retina and Optic Nerve
Attention for Chapter 17: 3D Histomorphometric Reconstruction and Quantification of the Optic Nerve Head Connective Tissues
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Chapter title
3D Histomorphometric Reconstruction and Quantification of the Optic Nerve Head Connective Tissues
Chapter number 17
Book title
Glaucoma
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7407-8_17
Pubmed ID
Book ISBNs
978-1-4939-7406-1, 978-1-4939-7407-8
Authors

Hongli Yang, Juan Reynaud, Howard Lockwood, Galen Williams, Christy Hardin, Luke Reyes, Stuart K. Gardiner, Claude F. Burgoyne

Abstract

Accurately characterizing the 3D geometry of the optic nerve head neural and connective tissues has been the goal of a large and important body of scientific work. In the present report, we summarize our methods for the high-resolution, digital, 3D histomorphometric reconstruction of the optic nerve head tissues, including their visualization, parameterization, and quantification. In addition, we present our methods for between-eye comparisons of this anatomy, and their use to determine animal-specific and experiment-wide experimental glaucoma versus Control eye differences in the unilateral, monkey experimental glaucoma model. Finally, we demonstrate its application to finite element modeling, 3D optic nerve head reconstruction of other species, and 3D optic nerve head reconstructions using other imaging modalities.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 1 17%
Student > Bachelor 1 17%
Student > Doctoral Student 1 17%
Professor 1 17%
Researcher 1 17%
Other 1 17%
Readers by discipline Count As %
Medicine and Dentistry 4 67%
Unspecified 1 17%
Unknown 1 17%