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Hypoxia and Exercise

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Cover of 'Hypoxia and Exercise'

Table of Contents

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    Book Overview
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    Chapter 1 A Tribute to John Burden West
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    Chapter 2 Adventures in High-Altitude Physiology
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    Chapter 3 Exercise induced arterial hypoxemia: the role of ventilation-perfusion inequality and pulmonary diffusion limitation.
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    Chapter 4 Intrapulmonary Shunt During Normoxic and Hypoxic Exercise in Healthy Humans
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    Chapter 5 Exercise-induced arterial hypoxemia: consequences for locomotor muscle fatigue.
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    Chapter 6 Mechanisms of Sleep Apnea at Altitude
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    Chapter 7 Control of cerebral blood flow during sleep and the effects of hypoxia.
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    Chapter 8 Neural consequences of sleep disordered breathing: the role of intermittent hypoxia.
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    Chapter 9 Finding the Genes Underlying Adaptation to Hypoxia Using Genomic Scans for Genetic Adaptation and Admixture Mapping
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    Chapter 10 An Evolutionary Model for Identifying Genetic Adaptation to High Altitude
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    Chapter 11 Hypoxic Preconditioning and Erythropoietin Protect Retinal Neurons from Degeneration
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    Chapter 12 Blocking Stress Signaling Pathways with Cell Permeable Peptides
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    Chapter 13 JNK Pathway as Therapeutic Target to Prevent Degeneration in the Central Nervous System
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    Chapter 14 Salvage Of Ischemic Myocardium: A Focus on JNK
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    Chapter 15 Mitochondrial Reactive Oxygen Species are Required for Hypoxic HIFα Stabilization
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    Chapter 16 Hypoxia-Induced Gene Activity in Disused Oxidative Muscle
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    Chapter 17 Role of the Red Blood Cell in Nitric Oxide Homeostasis and Hypoxic Vasodilation
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    Chapter 18 Expression of the Heterotrimeric G Protein Gi and ATP Release are Impaired in Erythrocytes of Humans with Diabetes Mellitus
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    Chapter 19 Red Blood Cells and Hemoglobin in Hypoxic Pulmonary Vasoconstriction
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    Chapter 20 Dose-Response of Altitude Training: How Much Altitude is Enough?
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    Chapter 21 The eye at altitude.
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    Chapter 22 Lake Louise Consensus Methods for Measuring the Hypoxic Ventilatory Response
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    Chapter 23 Pulmonary Hypertension in High-Altitude Dwellers: Novel Mechanisms, Unsuspected Predisposing Factors
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    Chapter 24 Gene Hunting in Hypoxia and Exercise
Attention for Chapter 7: Control of cerebral blood flow during sleep and the effects of hypoxia.
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Chapter title
Control of cerebral blood flow during sleep and the effects of hypoxia.
Chapter number 7
Book title
Hypoxia and Exercise
Published in
Advances in experimental medicine and biology, January 2006
DOI 10.1007/978-0-387-34817-9_7
Pubmed ID
Book ISBNs
978-0-387-34816-2, 978-0-387-34817-9

Corfield, Douglas R, Meadows, Guy E, Douglas R. Corfield, Guy E. Meadows


During wakefulness, cerebral blood flow (CBF) is closely coupled to regional cerebral metabolism; however CBF is also strongly modulated by breathing, increasing in response to both hypercapnia and hypoxia. During stage III/IV non-rapid eye (NREM) sleep, cerebral metabolism and CBF decrease whilst the partial pressure of arterial CO2 increases due to a reduction in alveolar ventilation. The reduction in CBF during NREM sleep therefore occurs despite a relative state of hypercapnia. We have used transcranial Doppler ultrasound to determine middle cerebral artery velocity, as an index of CBF, and have determined that NREM sleep is associated with a reduction in the cerebrovascular response to hypercapnia. This reduction in reactivity would, at least in part, allow the observed reductions in CBF in this state. Similarly, we have observed that the CBF response to hypoxia is absent during stage III/IV NREM sleep. Nocturnal hypoxia and hypercapnia are major pathogenic factor associated with cardio-respiratory diseases. These marked changes in cerebrovascular control that occur during sleep suggest that the cerebral circulation may be particularly vulnerable to cardio-respiratory insults during this period.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 7%
Spain 1 7%
Canada 1 7%
Unknown 12 80%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 33%
Professor > Associate Professor 3 20%
Student > Ph. D. Student 2 13%
Student > Master 1 7%
Professor 1 7%
Other 2 13%
Unknown 1 7%
Readers by discipline Count As %
Medicine and Dentistry 6 40%
Agricultural and Biological Sciences 3 20%
Psychology 2 13%
Engineering 2 13%
Neuroscience 1 7%
Other 0 0%
Unknown 1 7%