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Hypoxia and Exercise

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Cover of 'Hypoxia and Exercise'

Table of Contents

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    Book Overview
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    Chapter 1 A Tribute to John Burden West
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    Chapter 2 Adventures in High-Altitude Physiology
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    Chapter 3 Exercise induced arterial hypoxemia: the role of ventilation-perfusion inequality and pulmonary diffusion limitation.
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    Chapter 4 Intrapulmonary Shunt During Normoxic and Hypoxic Exercise in Healthy Humans
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    Chapter 5 Exercise-induced arterial hypoxemia: consequences for locomotor muscle fatigue.
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    Chapter 6 Mechanisms of Sleep Apnea at Altitude
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    Chapter 7 Control of cerebral blood flow during sleep and the effects of hypoxia.
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    Chapter 8 Neural consequences of sleep disordered breathing: the role of intermittent hypoxia.
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    Chapter 9 Finding the Genes Underlying Adaptation to Hypoxia Using Genomic Scans for Genetic Adaptation and Admixture Mapping
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    Chapter 10 An Evolutionary Model for Identifying Genetic Adaptation to High Altitude
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    Chapter 11 Hypoxic Preconditioning and Erythropoietin Protect Retinal Neurons from Degeneration
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    Chapter 12 Blocking Stress Signaling Pathways with Cell Permeable Peptides
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    Chapter 13 JNK Pathway as Therapeutic Target to Prevent Degeneration in the Central Nervous System
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    Chapter 14 Salvage Of Ischemic Myocardium: A Focus on JNK
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    Chapter 15 Mitochondrial Reactive Oxygen Species are Required for Hypoxic HIFα Stabilization
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    Chapter 16 Hypoxia-Induced Gene Activity in Disused Oxidative Muscle
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    Chapter 17 Role of the Red Blood Cell in Nitric Oxide Homeostasis and Hypoxic Vasodilation
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    Chapter 18 Expression of the Heterotrimeric G Protein Gi and ATP Release are Impaired in Erythrocytes of Humans with Diabetes Mellitus
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    Chapter 19 Red Blood Cells and Hemoglobin in Hypoxic Pulmonary Vasoconstriction
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    Chapter 20 Dose-Response of Altitude Training: How Much Altitude is Enough?
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    Chapter 21 The eye at altitude.
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    Chapter 22 Lake Louise Consensus Methods for Measuring the Hypoxic Ventilatory Response
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    Chapter 23 Pulmonary Hypertension in High-Altitude Dwellers: Novel Mechanisms, Unsuspected Predisposing Factors
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    Chapter 24 Gene Hunting in Hypoxia and Exercise
Attention for Chapter 5: Exercise-induced arterial hypoxemia: consequences for locomotor muscle fatigue.
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37 Mendeley
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Chapter title
Exercise-induced arterial hypoxemia: consequences for locomotor muscle fatigue.
Chapter number 5
Book title
Hypoxia and Exercise
Published in
Advances in experimental medicine and biology, January 2006
DOI 10.1007/978-0-387-34817-9_5
Pubmed ID
Book ISBNs
978-0-387-34816-2, 978-0-387-34817-9

Romer, Lee M, Dempsey, Jerome A, Lovering, Andrew, Eldridge, Marlowe, Lee M. Romer, Jerome A. Dempsey, Andrew Lovering, Marlowe Eldridge


Reductions in arterial O2 saturation (-5 to -10% SaO2 < rest) occur over time during sustained heavy intensity exercise in a normoxic environment, due primarily to the effects of acid pH and increased temperature on the position of the HbO2 dissociation curve. We prevented the desaturation via increased F1O2 (.23 to .29) and showed that exercise time to exhaustion was increased. We used supramaximal magnetic stimulation (1 - 100 Hz) of the femoral nerve to test for quadriceps fatigue. We used mildly hyperoxic inspirates (F1O2 .23 to .29) to prevent O2 desaturation. We then compared the amount of quadriceps fatigue incurred following cycling exercise at SaO2 98% vs. 91% with each trial carried out at equal exercise intensities (90% Max) and for equal durations. Preventing the normal exercise-induced O2 desaturation prevented about one-half the amount of exercise-induced quadriceps fatigue; plasma lactate and effort perception were also reduced. We conclude that the normal exercise-induced O2 desaturation during heavy intensity endurance exercise contributes significantly to exercise performance limitation in part because of its effect on locomotor muscle fatigue. These effects of EIAH were confirmed in mild environmental hypoxia (FIO2 .17, SaO2 88%) which significantly augmented the magnitude of exercise-induced quadriceps fatigue observed in normoxia.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Canada 1 3%
Unknown 35 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 22%
Researcher 6 16%
Student > Master 5 14%
Professor > Associate Professor 3 8%
Lecturer 3 8%
Other 10 27%
Unknown 2 5%
Readers by discipline Count As %
Medicine and Dentistry 16 43%
Sports and Recreations 9 24%
Agricultural and Biological Sciences 4 11%
Neuroscience 2 5%
Psychology 2 5%
Other 2 5%
Unknown 2 5%