↓ Skip to main content

Hypoxia and Exercise

Overview of attention for book
Cover of 'Hypoxia and Exercise'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 A Tribute to John Burden West
  3. Altmetric Badge
    Chapter 2 Adventures in High-Altitude Physiology
  4. Altmetric Badge
    Chapter 3 Exercise induced arterial hypoxemia: the role of ventilation-perfusion inequality and pulmonary diffusion limitation.
  5. Altmetric Badge
    Chapter 4 Intrapulmonary Shunt During Normoxic and Hypoxic Exercise in Healthy Humans
  6. Altmetric Badge
    Chapter 5 Exercise-induced arterial hypoxemia: consequences for locomotor muscle fatigue.
  7. Altmetric Badge
    Chapter 6 Mechanisms of Sleep Apnea at Altitude
  8. Altmetric Badge
    Chapter 7 Control of cerebral blood flow during sleep and the effects of hypoxia.
  9. Altmetric Badge
    Chapter 8 Neural consequences of sleep disordered breathing: the role of intermittent hypoxia.
  10. Altmetric Badge
    Chapter 9 Finding the Genes Underlying Adaptation to Hypoxia Using Genomic Scans for Genetic Adaptation and Admixture Mapping
  11. Altmetric Badge
    Chapter 10 An Evolutionary Model for Identifying Genetic Adaptation to High Altitude
  12. Altmetric Badge
    Chapter 11 Hypoxic Preconditioning and Erythropoietin Protect Retinal Neurons from Degeneration
  13. Altmetric Badge
    Chapter 12 Blocking Stress Signaling Pathways with Cell Permeable Peptides
  14. Altmetric Badge
    Chapter 13 JNK Pathway as Therapeutic Target to Prevent Degeneration in the Central Nervous System
  15. Altmetric Badge
    Chapter 14 Salvage Of Ischemic Myocardium: A Focus on JNK
  16. Altmetric Badge
    Chapter 15 Mitochondrial Reactive Oxygen Species are Required for Hypoxic HIFα Stabilization
  17. Altmetric Badge
    Chapter 16 Hypoxia-Induced Gene Activity in Disused Oxidative Muscle
  18. Altmetric Badge
    Chapter 17 Role of the Red Blood Cell in Nitric Oxide Homeostasis and Hypoxic Vasodilation
  19. Altmetric Badge
    Chapter 18 Expression of the Heterotrimeric G Protein Gi and ATP Release are Impaired in Erythrocytes of Humans with Diabetes Mellitus
  20. Altmetric Badge
    Chapter 19 Red Blood Cells and Hemoglobin in Hypoxic Pulmonary Vasoconstriction
  21. Altmetric Badge
    Chapter 20 Dose-Response of Altitude Training: How Much Altitude is Enough?
  22. Altmetric Badge
    Chapter 21 The eye at altitude.
  23. Altmetric Badge
    Chapter 22 Lake Louise Consensus Methods for Measuring the Hypoxic Ventilatory Response
  24. Altmetric Badge
    Chapter 23 Pulmonary Hypertension in High-Altitude Dwellers: Novel Mechanisms, Unsuspected Predisposing Factors
  25. Altmetric Badge
    Chapter 24 Gene Hunting in Hypoxia and Exercise
Attention for Chapter 5: Exercise-induced arterial hypoxemia: consequences for locomotor muscle fatigue.
Altmetric Badge

Citations

dimensions_citation
7 Dimensions

Readers on

mendeley
37 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
Exercise-induced arterial hypoxemia: consequences for locomotor muscle fatigue.
Chapter number 5
Book title
Hypoxia and Exercise
Published in
Advances in experimental medicine and biology, January 2006
DOI 10.1007/978-0-387-34817-9_5
Pubmed ID
Book ISBNs
978-0-387-34816-2, 978-0-387-34817-9
Authors

Romer, Lee M, Dempsey, Jerome A, Lovering, Andrew, Eldridge, Marlowe, Lee M. Romer, Jerome A. Dempsey, Andrew Lovering, Marlowe Eldridge

Abstract

Reductions in arterial O2 saturation (-5 to -10% SaO2 < rest) occur over time during sustained heavy intensity exercise in a normoxic environment, due primarily to the effects of acid pH and increased temperature on the position of the HbO2 dissociation curve. We prevented the desaturation via increased F1O2 (.23 to .29) and showed that exercise time to exhaustion was increased. We used supramaximal magnetic stimulation (1 - 100 Hz) of the femoral nerve to test for quadriceps fatigue. We used mildly hyperoxic inspirates (F1O2 .23 to .29) to prevent O2 desaturation. We then compared the amount of quadriceps fatigue incurred following cycling exercise at SaO2 98% vs. 91% with each trial carried out at equal exercise intensities (90% Max) and for equal durations. Preventing the normal exercise-induced O2 desaturation prevented about one-half the amount of exercise-induced quadriceps fatigue; plasma lactate and effort perception were also reduced. We conclude that the normal exercise-induced O2 desaturation during heavy intensity endurance exercise contributes significantly to exercise performance limitation in part because of its effect on locomotor muscle fatigue. These effects of EIAH were confirmed in mild environmental hypoxia (FIO2 .17, SaO2 88%) which significantly augmented the magnitude of exercise-induced quadriceps fatigue observed in normoxia.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Canada 1 3%
Unknown 35 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 22%
Researcher 6 16%
Student > Master 5 14%
Professor > Associate Professor 3 8%
Lecturer 3 8%
Other 10 27%
Unknown 2 5%
Readers by discipline Count As %
Medicine and Dentistry 16 43%
Sports and Recreations 9 24%
Agricultural and Biological Sciences 4 11%
Neuroscience 2 5%
Psychology 2 5%
Other 2 5%
Unknown 2 5%