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The Molecular Biology of Photorhabdus Bacteria

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Attention for Chapter 51: Identifying Anti-host Effectors in Photorhabdus
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Chapter title
Identifying Anti-host Effectors in Photorhabdus
Chapter number 51
Book title
The Molecular Biology of Photorhabdus Bacteria
Published in
Current topics in microbiology and immunology, January 2016
DOI 10.1007/82_2016_51
Pubmed ID
Book ISBNs
978-3-31-952714-7, 978-3-31-952715-4
Authors

Andrea J. Dowling

Abstract

The death of the insect host is an essential part of the life cycle of Photorhabdus, and as a result, this bacterium comes equipped with a dazzlingly large array of toxins and virulence factors that ensure rapid insect death. Elucidation of the key players in insect infection and mortality has therefore proved difficult using traditional microbiological techniques such as individual gene knockouts due to the high level of functional redundancy displayed by Photorhabdus virulence factors. Thus, knockout of any individual toxin gene may serve to delay time to death but not to render the bacteria avirulent due to the continued presence of an array of other toxins and virulence factors in the single-gene mutant. This functional redundancy had led to the necessary development of an array of techniques and new model systems for identifying and dissecting apart the action of anti-insect effectors produced by Photorhabdus. These have been pivotal in both the identification of new toxins and virulence factors and in ascribing functions to them. These techniques have gone on to prove valuable in pathogenic bacteria other than Photorhabdus and are likely to be useful in many others.

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 50%
Researcher 1 25%
Unknown 1 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 50%
Agricultural and Biological Sciences 1 25%
Unknown 1 25%