Chapter title |
Modulation of inflammatory cytokines by omega-3 fatty acids.
|
---|---|
Chapter number | 5 |
Book title |
Lipids in Health and Disease
|
Published in |
Sub cellular biochemistry, August 2008
|
DOI | 10.1007/978-1-4020-8831-5_5 |
Pubmed ID | |
Book ISBNs |
978-1-4020-8830-8, 978-1-4020-8831-5
|
Authors |
Kang JX, Weylandt KH, Kang, Jing X., Weylandt, Karsten H., Jing X. Kang, Karsten H. Weylandt |
Abstract |
Many human diseases have been linked to inflammation, which is mediated by a number of chemical molecules including lipid mediators and cytokines. Polyunsaturated fatty acids (omega-6 and omega-3 fatty acids) are the precursors of the lipid mediators and play an important role in regulation of inflammation. Generally, omega-6 fatty acids (e.g. arachidonic acid) promote inflammation whereas omega-3 fatty acids (e.g. eicosapentaenoic acid and docosahexaenoic acid) have anti-inflammatory properties. Omega-3 fatty acids dampen inflammation through multiple pathways. On the one hand, omega-3 fatty acids inhibit the formation of omega-6 fatty acids-derived pro-inflammatory eicosanoids (e.g. PGE2 and LTB4), and on the other hand these fatty acids can form several potent anti-inflammatory lipid mediators (e.g. resolvins and protectins). These together directly or indirectly suppress the activity of nuclear transcription factors, such as NFkappaB, and reduce the production of pro-inflammatory enzymes and cytokines, including COX-2, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1beta. This chapter focuses on the evidence from recent studies using new experimental models. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 127 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 26 | 20% |
Student > Ph. D. Student | 15 | 12% |
Researcher | 13 | 10% |
Student > Bachelor | 12 | 9% |
Student > Doctoral Student | 10 | 8% |
Other | 22 | 17% |
Unknown | 29 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 28 | 22% |
Agricultural and Biological Sciences | 23 | 18% |
Biochemistry, Genetics and Molecular Biology | 18 | 14% |
Neuroscience | 7 | 6% |
Nursing and Health Professions | 5 | 4% |
Other | 12 | 9% |
Unknown | 34 | 27% |