↓ Skip to main content

Lipids in Health and Disease

Overview of attention for book
Cover of 'Lipids in Health and Disease'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Transcriptional Regulation of Hepatic Fatty Acid Metabolism
  3. Altmetric Badge
    Chapter 2 Modulation of Protein Function by Isoketals and Levuglandins
  4. Altmetric Badge
    Chapter 3 Signalling Pathways Controlling Fatty Acid Desaturation
  5. Altmetric Badge
    Chapter 4 Fatty acid amide hydrolase: a gate-keeper of the endocannabinoid system.
  6. Altmetric Badge
    Chapter 5 Modulation of inflammatory cytokines by omega-3 fatty acids.
  7. Altmetric Badge
    Chapter 6 Eicosanoids in Tumor Progression and Metastasis
  8. Altmetric Badge
    Chapter 7 Fatty Acid Synthase Activity in Tumor Cells
  9. Altmetric Badge
    Chapter 8 Lipids in the Assembly of Membrane Proteins and Organization of Protein Supercomplexes: Implications for Lipid-linked Disorders
  10. Altmetric Badge
    Chapter 9 Altered Lipid Metabolism in Brain Injury and Disorders
  11. Altmetric Badge
    Chapter 10 Lysophospholipid Activation of G Protein-Coupled Receptors
  12. Altmetric Badge
    Chapter 11 Phospholipid-Mediated Signaling and Heart Disease
  13. Altmetric Badge
    Chapter 12 The Role of Phospholipid Oxidation Products in Inflammatory and Autoimmune Diseases
  14. Altmetric Badge
    Chapter 13 Mediation of Apoptosis by Oxidized Phospholipids
  15. Altmetric Badge
    Chapter 14 Regulation of lipid metabolism by sphingolipids
  16. Altmetric Badge
    Chapter 15 Multiple Roles for Sphingolipids in Steroid Hormone Biosynthesis
  17. Altmetric Badge
    Chapter 16 Roles of Bioactive Sphingolipids in Cancer Biology and Therapeutics
  18. Altmetric Badge
    Chapter 17 Glycosphingolipid Disorders of the Brain
  19. Altmetric Badge
    Chapter 18 Role of Neutral Sphingomyelinases in Aging and Inflammation
  20. Altmetric Badge
    Chapter 19 Sphingolipid Metabolizing Enzymes as Novel Therapeutic Targets
  21. Altmetric Badge
    Chapter 20 Ceramide-Enriched Membrane Domains in Infectious Biology and Development
  22. Altmetric Badge
    Chapter 21 MALDI-TOF MS analysis of lipids from cells, tissues and body fluids.
  23. Altmetric Badge
    Chapter 22 Lipidomics in diagnosis of lipidoses
Attention for Chapter 9: Altered Lipid Metabolism in Brain Injury and Disorders
Altmetric Badge

Mentioned by

twitter
2 X users

Citations

dimensions_citation
32 Dimensions

Readers on

mendeley
405 Mendeley
citeulike
1 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
Altered Lipid Metabolism in Brain Injury and Disorders
Chapter number 9
Book title
Lipids in Health and Disease
Published in
Sub cellular biochemistry, February 2016
DOI 10.1007/978-1-4020-8831-5_9
Pubmed ID
Book ISBNs
978-1-4020-8830-8, 978-1-4020-8831-5
Authors

Rao Muralikrishna Adibhatla, J. F. Hatcher, Adibhatla, Rao Muralikrishna, Hatcher, J. F.

Abstract

Deregulated lipid metabolism may be of particular importance for CNS injuries and disorders, as this organ has the highest lipid concentration next to adipose tissue. Atherosclerosis (a risk factor for ischemic stroke) results from accumulation of LDL-derived lipids in the arterial wall. Pro-inflammatory cytokines (TNF-alpha and IL-1), secretory phospholipase A2 IIA and lipoprotein-PLA2 are implicated in vascular inflammation. These inflammatory responses promote atherosclerotic plaques, formation and release of the blood clot that can induce ischemic stroke. TNF-alpha and IL-1 alter lipid metabolism and stimulate production of eicosanoids, ceramide, and reactive oxygen species that potentiate CNS injuries and certain neurological disorders. Cholesterol is an important regulator of lipid organization and the precursor for neurosteroid biosynthesis. Low levels of neurosteroids were related to poor outcome in many brain pathologies. Apolipoprotein E is the principal cholesterol carrier protein in the brain, and the gene encoding the variant Apolipoprotein E4 is a significant risk factor for Alzheimer's disease. Parkinson's disease is to some degree caused by lipid peroxidation due to phospholipases activation. Niemann-Pick diseases A and B are due to acidic sphingomyelinase deficiency, resulting in sphingomyelin accumulation, while Niemann-Pick disease C is due to mutations in either the NPC1 or NPC2 genes, resulting in defective cholesterol transport and cholesterol accumulation. Multiple sclerosis is an autoimmune inflammatory demyelinating condition of the CNS. Inhibiting phospholipase A2 attenuated the onset and progression of experimental autoimmune encephalomyelitis. The endocannabinoid system is hypoactive in Huntington's disease. Ethyl-eicosapetaenoate showed promise in clinical trials. Amyotrophic lateral sclerosis causes loss of motorneurons. Cyclooxygenase-2 inhibition reduced spinal neurodegeneration in amyotrophic lateral sclerosis transgenic mice. Eicosapentaenoic acid supplementation provided improvement in schizophrenia patients, while the combination of (eicosapentaenoic acid + docosahexaenoic acid) provided benefit in bipolar disorders. The ketogenic diet where >90% of calories are derived from fat is an effective treatment for epilepsy. Understanding cytokine-induced changes in lipid metabolism will promote novel concepts and steer towards bench-to-bedside transition for therapies.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 405 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
Netherlands 1 <1%
Belgium 1 <1%
Australia 1 <1%
Spain 1 <1%
Russia 1 <1%
Unknown 397 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 62 15%
Researcher 57 14%
Student > Master 41 10%
Student > Bachelor 41 10%
Student > Doctoral Student 30 7%
Other 78 19%
Unknown 96 24%
Readers by discipline Count As %
Medicine and Dentistry 94 23%
Agricultural and Biological Sciences 61 15%
Neuroscience 44 11%
Biochemistry, Genetics and Molecular Biology 30 7%
Psychology 15 4%
Other 44 11%
Unknown 117 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2022.
All research outputs
#19,942,460
of 25,382,035 outputs
Outputs from Sub cellular biochemistry
#255
of 391 outputs
Outputs of similar age
#284,312
of 407,746 outputs
Outputs of similar age from Sub cellular biochemistry
#12
of 15 outputs
Altmetric has tracked 25,382,035 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 391 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 407,746 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.