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Caspases,Paracaspases, and Metacaspases

Overview of attention for book
Attention for Chapter 11: Detection and Measurement of Paracaspase MALT1 Activity.
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Chapter title
Detection and Measurement of Paracaspase MALT1 Activity.
Chapter number 11
Book title
Caspases,Paracaspases, and Metacaspases
Published in
Methods in molecular biology, February 2014
DOI 10.1007/978-1-4939-0357-3_11
Pubmed ID
Book ISBNs
978-1-4939-0356-6, 978-1-4939-0357-3
Authors

Hailfinger S, Pelzer C, Thome M, Stephan Hailfinger, Christiane Pelzer, Margot Thome

Abstract

The paracaspase MALT1 is a Cys-dependent, Arg-specific protease that plays an essential role in the activation and proliferation of lymphocytes during the immune response. Oncogenic activation of MALT1 is associated with the development of specific forms of B-cell lymphomas. Through specific cleavage of its substrates, MALT1 controls various aspects of lymphocyte activation, including the activation of transcriptional pathways, the stabilization of mRNAs, and an increase in cellular adhesion. In lymphocytes, the activity of MALT1 is tightly controlled by its inducible monoubiquitination, which promotes the dimerization of MALT1. Here, we describe both in vitro and in vivo assays that have been developed to assess MALT1 activity.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 3 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 1 33%
Unknown 2 67%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 33%
Unknown 2 67%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2014.
All research outputs
#3,419,960
of 4,382,167 outputs
Outputs from Methods in molecular biology
#1,745
of 3,003 outputs
Outputs of similar age
#89,390
of 117,607 outputs
Outputs of similar age from Methods in molecular biology
#50
of 74 outputs
Altmetric has tracked 4,382,167 research outputs across all sources so far. This one is in the 2nd percentile – i.e., 2% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,003 research outputs from this source. They receive a mean Attention Score of 1.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 117,607 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.