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Caspases,Paracaspases, and Metacaspases

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Attention for Chapter 6: Caspase Protocols in Caenorhabditis elegans.
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Chapter title
Caspase Protocols in Caenorhabditis elegans.
Chapter number 6
Book title
Caspases,Paracaspases, and Metacaspases
Published in
Methods in molecular biology, February 2014
DOI 10.1007/978-1-4939-0357-3_6
Pubmed ID
Book ISBNs
978-1-4939-0356-6, 978-1-4939-0357-3
Authors

Lee ES, Xue D, Eui Seung Lee, Ding Xue

Abstract

Caenorhabditis elegans genome has four genes (ced-3, csp-1, csp-2, and csp-3) encoding caspase-like proteins. Among these four proteins, CED-3 is the most well-known cell-killing caspase. Elucidation of the role of CED-3 as a central component of the apoptotic pathway in C. elegans has contributed to the understanding of the more complex apoptosis network in mammals and in other metazoa. In the highly conserved pathway of programmed cell death in C. elegans, CED-3 functions at the terminal step of this cell-killing pathway. Identification of CED-3 caspase substrates is essential for bridging the gaps between CED-3 activation and various downstream cell death execution events. If a protein is cleaved by CED-3 in vitro, this protein could be a potential CED-3 substrate in vivo. Here, we describe the method for purification of active CED-3 caspase. We will also describe in vitro assays for determining CED-3 proteolytic activity, CED-3 substrates, and CED-3 cleavage sites in the substrates.

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Geographical breakdown

Country Count As %
Unknown 1 100%

Demographic breakdown

Readers by professional status Count As %
Other 1 100%
Readers by discipline Count As %
Agricultural and Biological Sciences 1 100%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2014.
All research outputs
#8,461,695
of 9,699,854 outputs
Outputs from Methods in molecular biology
#5,063
of 7,425 outputs
Outputs of similar age
#165,018
of 203,309 outputs
Outputs of similar age from Methods in molecular biology
#55
of 75 outputs
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