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Multiple Sclerosis

Overview of attention for book
Cover of 'Multiple Sclerosis'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 87 Multiple Sclerosis
  3. Altmetric Badge
    Chapter 88 Experimental Autoimmune Encephalomyelitis in Mice
  4. Altmetric Badge
    Chapter 99 Peripheral Blood Mononuclear Cells: Isolation, Freezing, Thawing, and Culture
  5. Altmetric Badge
    Chapter 107 Generation of Transgenic Rats Using Lentiviral Vectors
  6. Altmetric Badge
    Chapter 108 Positional Gene Cloning in Experimental Populations
  7. Altmetric Badge
    Chapter 110 Neuropathological Techniques to Investigate CNS Pathology in Experimental Autoimmune Encephalomyelitis (EAE)
  8. Altmetric Badge
    Chapter 111 ELISPOT Techniques
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    Chapter 113 Experimental Autoimmune Encephalomyelitis in Marmosets
  10. Altmetric Badge
    Chapter 114 Isolation of Central Nervous System (CNS) Infiltrating Cells
  11. Altmetric Badge
    Chapter 129 Myelinating Cultures: An In Vitro Tool to Identify Demyelinating and Axopathic Autoantibodies
  12. Altmetric Badge
    Chapter 150 In Vivo Visualization of (Auto)Immune Processes in the Central Nervous System of Rodents.
  13. Altmetric Badge
    Chapter 151 Neuropathological Techniques to Investigate Central Nervous System Sections in Multiple Sclerosis
  14. Altmetric Badge
    Chapter 153 Optical Coherence Tomography to Assess Neurodegeneration in Multiple Sclerosis.
  15. Altmetric Badge
    Chapter 177 Actively Induced Experimental Autoimmune Encephalomyelitis in Rats
  16. Altmetric Badge
    Chapter 206 Neurofilament Light Chain Determination from Peripheral Blood Samples
  17. Altmetric Badge
    Chapter 222 Methods for Ex Vivo Analysis of Immune Cell Function from the Central Nervous System
  18. Altmetric Badge
    Chapter 223 Detection of Autoantibodies Against Myelin Oligodendrocyte Glycoprotein in Multiple Sclerosis and Related Diseases
Attention for Chapter 150: In Vivo Visualization of (Auto)Immune Processes in the Central Nervous System of Rodents.
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

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Citations

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Chapter title
In Vivo Visualization of (Auto)Immune Processes in the Central Nervous System of Rodents.
Chapter number 150
Book title
Multiple Sclerosis
Published in
Methods in molecular biology, December 2014
DOI 10.1007/7651_2014_150
Pubmed ID
Book ISBNs
978-1-4939-2629-9, 978-1-4939-2630-5
Authors

Christian Schläger, Tanja Litke, Alexander Flügel, Francesca Odoardi, Schläger C, Litke T, Flügel A, Odoardi F

Abstract

The CNS is effectively shielded from the periphery by the blood-brain barrier (BBB) which limits the entry of cells and solutes. However, in autoimmune disorders such as multiple sclerosis, immune cells can overcome this barrier and induce the formation of CNS inflammatory lesions. Recently, two-photon laser scanning microscopy (TPLSM) has made it possible to visualize autoimmune processes in the living CNS in real time. However, along with a high microscopy standard, this technique requires an advanced surgical procedure to access the region of interest. Here, we describe in detail the necessary methodological steps to visualize (auto)immune processes in living rodent tissue. We focus on the procedures to image the leptomeningeal vessels of the thoracic spinal cord during transfer experimental autoimmune encephalomyelitis in LEW rats (AT EAE) and in active EAE in C57BL/6 mice (aEAE).

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 47%
Professor > Associate Professor 2 13%
Student > Ph. D. Student 2 13%
Student > Master 1 7%
Professor 1 7%
Other 1 7%
Unknown 1 7%
Readers by discipline Count As %
Neuroscience 5 33%
Biochemistry, Genetics and Molecular Biology 2 13%
Immunology and Microbiology 1 7%
Agricultural and Biological Sciences 1 7%
Physics and Astronomy 1 7%
Other 3 20%
Unknown 2 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2016.
All research outputs
#3,742,823
of 7,659,635 outputs
Outputs from Methods in molecular biology
#1,590
of 5,430 outputs
Outputs of similar age
#105,835
of 235,968 outputs
Outputs of similar age from Methods in molecular biology
#158
of 619 outputs
Altmetric has tracked 7,659,635 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,430 research outputs from this source. They receive a mean Attention Score of 1.9. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,968 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 619 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.