Title |
Tumor-infiltrating B cells: their role and application in anti-tumor immunity in lung cancer
|
---|---|
Published in |
Cellular & Molecular Immunology, April 2018
|
DOI | 10.1038/s41423-018-0027-x |
Pubmed ID | |
Authors |
Si-si Wang, Wei Liu, Dalam Ly, Hao Xu, Limei Qu, Li Zhang |
Abstract |
Evidence indicates that lung cancer development is a complex process that involves interactions between tumor cells, stromal fibroblasts, and immune cells. Tumor-infiltrating immune cells play a significant role in the promotion or inhibition of tumor growth. As an integral component of the tumor microenvironment, tumor-infiltrating B lymphocytes (TIBs) exist in all stages of cancer and play important roles in shaping tumor development. Here, we review recent clinical and preclinical studies that outline the role of TIBs in lung cancer development, assess their prognostic significance, and explore the potential benefit of B cell-based immunotherapy for lung cancer treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 277 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 45 | 16% |
Student > Ph. D. Student | 42 | 15% |
Student > Master | 39 | 14% |
Student > Bachelor | 22 | 8% |
Student > Doctoral Student | 12 | 4% |
Other | 31 | 11% |
Unknown | 86 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 56 | 20% |
Immunology and Microbiology | 49 | 18% |
Medicine and Dentistry | 40 | 14% |
Agricultural and Biological Sciences | 17 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 2% |
Other | 16 | 6% |
Unknown | 94 | 34% |