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MicroRNA and Cancer

Overview of attention for book
Cover of 'MicroRNA and Cancer'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Noncoding RNAs in DNA Damage Response: Opportunities for Cancer Therapeutics
  3. Altmetric Badge
    Chapter 2 MicroRNAs in Breast Cancer: Diagnostic and Therapeutic Potential
  4. Altmetric Badge
    Chapter 3 Involvement of miRNAs and Pseudogenes in Cancer
  5. Altmetric Badge
    Chapter 4 MicroRNAs Reprogram Tumor Immune Response
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    Chapter 5 Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like Gene Expression, RNA Editing, and MicroRNAs Regulation
  7. Altmetric Badge
    Chapter 6 MicroRNAs Change the Landscape of Cancer Resistance
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    Chapter 7 MicroRNA, Noise, and Gene Expression Regulation
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    Chapter 8 Deep Sequencing Reveals a MicroRNA Expression Signature in Triple-Negative Breast Cancer
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    Chapter 9 Detection of Plasma MicroRNA Signature in Osteosarcoma Patients
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    Chapter 10 Identification of E6/E7-Dependent MicroRNAs in HPV-Positive Cancer Cells
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    Chapter 11 Combination of Anti-miRNAs Oligonucleotides with Low Amounts of Chemotherapeutic Agents for Pancreatic Cancer Therapy
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    Chapter 12 Evaluation of MicroRNA Delivery In Vivo
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    Chapter 13 Angiogenesis Analysis by In Vitro Coculture Assays in Transwell Chambers in Ovarian Cancer
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    Chapter 14 Application of Individual qPCR Performance Parameters for Quality Control of Circulating MicroRNA Data
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    Chapter 15 Construction of Multi-Potent MicroRNA Sponge and Its Functional Evaluation
  17. Altmetric Badge
    Chapter 16 MicroRNA Sequencing Data Analysis Toolkits
Attention for Chapter 1: Noncoding RNAs in DNA Damage Response: Opportunities for Cancer Therapeutics
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  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

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Chapter title
Noncoding RNAs in DNA Damage Response: Opportunities for Cancer Therapeutics
Chapter number 1
Book title
MicroRNA and Cancer
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7435-1_1
Pubmed ID
Book ISBNs
978-1-4939-7433-7, 978-1-4939-7435-1
Authors

Wani Arjumand, Asia Asiaf, Shiekh Tanveer Ahmad, Arjumand, Wani, Asiaf, Asia, Ahmad, Shiekh Tanveer

Abstract

DNA repair machinery preserves genomic integrity, which is frequently challenged through endogenous and exogenous toxic insults, and any sort of repair machinery malfunctioning ultimately manifests in the form of several types of terrible human diseases such as cancers (Hoeijmakers, Nature 411(6835): 366-374, 2001). Noncoding RNAs (ncRNAs) are crucial players of DNA repair machinery in a cell and play a vital role in maintaining genomic stability, which is essential for its survival and normal functioning thus preventing tumorigenesis. To preserve the integrity of the genome, cells initiate a specific cellular response, recognized as DNA damage response (DDR), which includes several distinct DNA repair pathways. These repair pathways permit normal cells to repair DNA damage or induce apoptosis and cell cycle arrest in case the damage is irreparable. Disruption of these pathways in cancer leads to an increase in genomic instability and mutagenesis. Recently, emerging evidence suggests that ncRNAs play a critical role in the regulation of DDR. There is an extensive crosstalk between ncRNAs and the canonical DDR signaling pathway. DDR-induced expression of ncRNAs can provide a regulatory mechanism to accurately control the expression of DNA damage responsive genes in a spatio-temporal manner. DNA damage alters expression of a variety of ncRNAs at multiple levels including transcriptional regulation, post-transcriptional regulation, and RNA degradation and vice versa, wherein ncRNAs can directly regulate cellular processes involved in DDR by altering expression of their targeting genes, with a particular emphasis on microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). Relationship between the defects in the DDR and deregulation of related ncRNAs in human cancers is one of the established, which is growing stronger with the advent of high-throughput sequencing techniques such as next-generation sequencing. Understanding of the mechanisms that explain the association between ncRNAs and DDR/DNA repair pathways will definitely increase our understanding on human tumor biology and on different responses to diverse drugs. Different ncRNAs interact with distinct DDR components and are promising targets for improving the effects to overcome the resistance to conventional chemotherapeutic agents. In this chapter, we will focus the role of ncRNAs in the DNA damage, repair, and cancer.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 27%
Researcher 5 19%
Professor > Associate Professor 2 8%
Other 1 4%
Student > Bachelor 1 4%
Other 3 12%
Unknown 7 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 35%
Agricultural and Biological Sciences 3 12%
Arts and Humanities 2 8%
Unspecified 1 4%
Chemistry 1 4%
Other 0 0%
Unknown 10 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2017.
All research outputs
#14,957,976
of 23,007,053 outputs
Outputs from Methods in molecular biology
#4,728
of 13,159 outputs
Outputs of similar age
#255,656
of 442,275 outputs
Outputs of similar age from Methods in molecular biology
#508
of 1,498 outputs
Altmetric has tracked 23,007,053 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,159 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 442,275 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,498 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.