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Cyclin-Dependent Kinase (CDK) Inhibitors

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Cover of 'Cyclin-Dependent Kinase (CDK) Inhibitors'

Table of Contents

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    Book Overview
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    Chapter 1 Cyclin-Dependent Kinase (CDK) Inhibitors
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    Chapter 2 Expression and Purification of Recombinant Cyclins and CDKs for Activity Evaluation
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    Chapter 3 Expression and Purification of Recombinant CDKs: CDK7, CDK8, and CDK9
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    Chapter 4 Preparation of CDK/Cyclin Inhibitor Complexes for Structural Determination
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    Chapter 5 Fragment-Based De Novo Design of Cyclin-Dependent Kinase 2 Inhibitors
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    Chapter 6 Protein-Protein Interaction for the De Novo Design of Cyclin-Dependent Kinase Peptide Inhibitors
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    Chapter 7 Identification of Cyclin A Binders with a Fluorescent Peptide Sensor
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    Chapter 8 Cyclin-Dependent Kinase (CDK) Inhibitors
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    Chapter 9 Analysis of CDK Inhibitor Action on Mitochondria-Mediated Apoptosis
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    Chapter 10 Evaluating the Effects of CDK Inhibitors in Ischemia–Reperfusion Injury Models
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    Chapter 11 Assessing Cell Cycle Independent Function of the CDK Inhibitor p21(CDKN1A) in DNA Repair.
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    Chapter 12 Drug Delivery Strategies of Chemical CDK Inhibitors
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    Chapter 13 Animal Models for Studying the In Vivo Functions of Cell Cycle CDKs.
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    Chapter 14 Evaluating Chemical CDK Inhibitors as Cell Death Inducers
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    Chapter 15 Models for the Study of the Cross Talk Between Inflammation and Cell Cycle
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    Chapter 16 Metabolomic Applications to the Characterization of the Mode-of-Action of CDK Inhibitors
Attention for Chapter 1: Cyclin-Dependent Kinase (CDK) Inhibitors
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Chapter title
Cyclin-Dependent Kinase (CDK) Inhibitors
Chapter number 1
Book title
Cyclin-Dependent Kinase (CDK) Inhibitors
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-2926-9_1
Pubmed ID
Book ISBNs
978-1-4939-2925-2, 978-1-4939-2926-9
Authors

Gallastegui, Edurne, Bachs, Oriol, Edurne Gallastegui, Oriol Bachs

Abstract

Cyclin-dependent kinases (Cdks) belong to a family of key regulators of cell division cycle and transcription. The activity of some of them is deregulated in tumor cells and to find specific inhibitors is an important goal to be achieved. We report here the current methods to determine their in vitro activity in order to facilitate the identification of specific inhibitors. Mainly, the activity can be determined by using immunoprecipitates from cell samples with antibodies against specific Cdks as a source of the enzymes.

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Mendeley readers

The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 2 100%

Demographic breakdown

Readers by professional status Count As %
Other 1 50%
Unknown 1 50%
Readers by discipline Count As %
Medicine and Dentistry 1 50%
Unknown 1 50%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2016.
All research outputs
#6,648,330
of 7,684,314 outputs
Outputs from Methods in molecular biology
#3,855
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Outputs of similar age
#223,869
of 267,935 outputs
Outputs of similar age from Methods in molecular biology
#11
of 17 outputs
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