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Human Cytomegaloviruses

Overview of attention for book
Cover of 'Human Cytomegaloviruses'

Table of Contents

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    Book Overview
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    Chapter 1 History of the molecular biology of cytomegaloviruses.
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    Chapter 2 Overview of Human Cytomegalovirus Pathogenesis
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    Chapter 3 Distinct Properties of Human Cytomegalovirus Strains and the Appropriate Choice of Strains for Particular Studies
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    Chapter 4 Use of Diploid Human Fibroblasts as a Model System to Culture, Grow, and Study Human Cytomegalovirus Infection
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    Chapter 5 Use of Recombinant Approaches to Construct Human Cytomegalovirus Mutants
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    Chapter 6 The use of primary human cells (fibroblasts, monocytes, and others) to assess human cytomegalovirus function.
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    Chapter 7 Hematopoietic Long-Term Culture (hLTC) for Human Cytomegalovirus Latency and Reactivation.
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    Chapter 8 Analysis of Cytomegalovirus Binding/Entry-Mediated Events
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    Chapter 9 Use of 5-Ethynyl-2′-Deoxyuridine Labelling and Flow Cytometry to Study Cell Cycle-Dependent Regulation of Human Cytomegalovirus Gene Expression
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    Chapter 10 Methods for Studying the Function of Cytomegalovirus GPCRs
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    Chapter 11 Methods for the Detection of Cytomegalovirus in Glioblastoma Cells and Tissues
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    Chapter 12 Methods to Study the Nucleocytoplasmic Transport of Macromolecules with Respect to Their Impact on the Regulation of Human Cytomegalovirus Gene Expression
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    Chapter 13 Fluorescence-Based Laser Capture Microscopy Technology Facilitates Identification of Critical In Vivo Cytomegalovirus Transcriptional Programs
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    Chapter 14 Techniques for Characterizing Cytomegalovirus-Encoded miRNAs.
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    Chapter 15 What We Have Learned from Animal Models of HCMV
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    Chapter 16 Rodent models of congenital cytomegalovirus infection.
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    Chapter 17 Recent approaches and strategies in the generation of antihuman cytomegalovirus vaccines.
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    Chapter 18 Approaches for the Generation of New Anti-cytomegalovirus Agents: Identification of Protein–Protein Interaction Inhibitors and Compounds Against the HCMV IE2 Protein
Attention for Chapter 16: Rodent models of congenital cytomegalovirus infection.
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Chapter title
Rodent models of congenital cytomegalovirus infection.
Chapter number 16
Book title
Human Cytomegaloviruses
Published in
Methods in molecular biology, March 2014
DOI 10.1007/978-1-62703-788-4_16
Pubmed ID
Book ISBNs
978-1-62703-787-7, 978-1-62703-788-4
Authors

Cekinovic D, Lisnic VJ, Jonjic S, Djurdjica Cekinovic, Vanda Juranic Lisnic, Stipan Jonjic

Abstract

Human cytomegalovirus (HCMV) is a leading viral cause of congenital infections in the central nervous system (CNS) and may result in severe long-term sequelae. High rates of sequelae following congenital HCMV infection and insufficient antiviral therapy in the perinatal period make the development of an HCMV-specific vaccine a high priority of modern medicine. Due to species specificity of HCMV, animal models are frequently used to study CMV pathogenesis. Studies of murine cytomegalovirus (MCMV) infections of adult mice have served a major role as a model of CMV biology and pathogenesis, while MCMV infection of newborn mice has been successfully used as a model of perinatal CMV infection. Newborn mice infected with MCMV have high levels of viremia during which the virus establishes productive infection in most organs, coupled with a strong inflammatory response. Productive infection in the brain parenchyma during early postnatal period leads to an extensive non-necrotizing multifocal widespread encephalitis characterized by infiltration of components of both innate and adaptive immunity. As a result, impairment in postnatal development of mouse cerebellum leads to long-term motor and sensor disabilities. This chapter summarizes current findings of rodent models of perinatal CMV infection and describes methods for analysis of perinatal MCMV infection in newborn mice.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 27%
Student > Ph. D. Student 2 18%
Other 1 9%
Student > Bachelor 1 9%
Student > Master 1 9%
Other 2 18%
Unknown 1 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 27%
Biochemistry, Genetics and Molecular Biology 2 18%
Medicine and Dentistry 2 18%
Immunology and Microbiology 2 18%
Psychology 1 9%
Other 1 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2014.
All research outputs
#3,170,113
of 4,483,765 outputs
Outputs from Methods in molecular biology
#1,458
of 3,175 outputs
Outputs of similar age
#76,745
of 106,873 outputs
Outputs of similar age from Methods in molecular biology
#65
of 124 outputs
Altmetric has tracked 4,483,765 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,175 research outputs from this source. They receive a mean Attention Score of 1.4. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 106,873 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 124 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.