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Human Cytomegaloviruses

Overview of attention for book
Cover of 'Human Cytomegaloviruses'

Table of Contents

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    Book Overview
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    Chapter 1 History of the molecular biology of cytomegaloviruses.
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    Chapter 2 Overview of Human Cytomegalovirus Pathogenesis
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    Chapter 3 Distinct Properties of Human Cytomegalovirus Strains and the Appropriate Choice of Strains for Particular Studies
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    Chapter 4 Use of Diploid Human Fibroblasts as a Model System to Culture, Grow, and Study Human Cytomegalovirus Infection
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    Chapter 5 Use of Recombinant Approaches to Construct Human Cytomegalovirus Mutants
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    Chapter 6 The use of primary human cells (fibroblasts, monocytes, and others) to assess human cytomegalovirus function.
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    Chapter 7 Hematopoietic Long-Term Culture (hLTC) for Human Cytomegalovirus Latency and Reactivation.
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    Chapter 8 Analysis of Cytomegalovirus Binding/Entry-Mediated Events
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    Chapter 9 Use of 5-Ethynyl-2′-Deoxyuridine Labelling and Flow Cytometry to Study Cell Cycle-Dependent Regulation of Human Cytomegalovirus Gene Expression
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    Chapter 10 Methods for Studying the Function of Cytomegalovirus GPCRs
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    Chapter 11 Methods for the Detection of Cytomegalovirus in Glioblastoma Cells and Tissues
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    Chapter 12 Methods to Study the Nucleocytoplasmic Transport of Macromolecules with Respect to Their Impact on the Regulation of Human Cytomegalovirus Gene Expression
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    Chapter 13 Fluorescence-Based Laser Capture Microscopy Technology Facilitates Identification of Critical In Vivo Cytomegalovirus Transcriptional Programs
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    Chapter 14 Techniques for Characterizing Cytomegalovirus-Encoded miRNAs.
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    Chapter 15 What We Have Learned from Animal Models of HCMV
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    Chapter 16 Rodent models of congenital cytomegalovirus infection.
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    Chapter 17 Recent approaches and strategies in the generation of antihuman cytomegalovirus vaccines.
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    Chapter 18 Approaches for the Generation of New Anti-cytomegalovirus Agents: Identification of Protein–Protein Interaction Inhibitors and Compounds Against the HCMV IE2 Protein
Attention for Chapter 17: Recent approaches and strategies in the generation of antihuman cytomegalovirus vaccines.
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Chapter title
Recent approaches and strategies in the generation of antihuman cytomegalovirus vaccines.
Chapter number 17
Book title
Human Cytomegaloviruses
Published in
Methods in molecular biology, March 2014
DOI 10.1007/978-1-62703-788-4_17
Pubmed ID
Book ISBNs
978-1-62703-787-7, 978-1-62703-788-4
Authors

Boppana SB, Britt WJ, Suresh B. Boppana, William J. Britt

Abstract

The development of prophylactic and to lesser extent therapeutic vaccines for the prevention of disease associated with human cytomegalovirus (HCMV) infections has received considerable attention from biomedical researchers and pharmaceutical companies over the previous 15 years, even though attempts to produce such vaccines have been described in the literature for over 40 years. Studies of the natural history of congenital HCMV infection and infection in allograft recipients have suggested that prophylaxis of disease associated with HCMV infection could be possible, particularly in hosts at risk for more severe disease secondary to the lack of preexisting immunity. Provided a substantial understanding of immune response to HCMV together with several animal models that faithfully recapitulate aspects of human infection and immunity, investigators seem well positioned to design and test candidate vaccines. Yet more recent studies of the role of a maternal immunity in the natural history of congenital HCMV infection, including the recognition that reinfection of previously immune women by genetically distinct strains of HCMV occur in populations with a high seroprevalence, have raised several questions about the nature of protective immunity in maternal populations. This finding coupled with observations that have documented a significant incidence of damaging congenital infections in offspring of women with immunity to HCMV prior to conception has suggested that vaccine development based on conventional paradigms of adaptive immunity to viral infections may be of limited value in the prevention of damaging congenital HCMV infections. Perhaps a more achievable goal will be prophylactic vaccines to modify HCMV associated disease in allograft transplant recipients. Although recent descriptions of the results from vaccine trials have been heralded as evidence of an emerging success in the quest for a HCMV vaccine, careful analyses of these studies have also revealed that major hurdles remain to be addressed by current strategies.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 20%
Student > Bachelor 4 20%
Researcher 3 15%
Student > Master 2 10%
Student > Postgraduate 2 10%
Other 4 20%
Unknown 1 5%
Readers by discipline Count As %
Medicine and Dentistry 11 55%
Psychology 4 20%
Mathematics 2 10%
Agricultural and Biological Sciences 1 5%
Unknown 2 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2014.
All research outputs
#3,448,075
of 4,483,765 outputs
Outputs from Methods in molecular biology
#1,766
of 3,175 outputs
Outputs of similar age
#92,719
of 125,425 outputs
Outputs of similar age from Methods in molecular biology
#46
of 70 outputs
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