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X Demographics
Mendeley readers
Attention Score in Context
| Chapter title |
Sphingosine Kinases as Druggable Targets
|
|---|---|
| Chapter number | 96 |
| Book title |
Lipid Signaling in Human Diseases
|
| Published in |
Handbook of experimental pharmacology, February 2018
|
| DOI | 10.1007/164_2018_96 |
| Pubmed ID | |
| Book ISBNs |
978-3-03-033667-7, 978-3-03-033668-4
|
| Authors |
Susan Pyne, David R. Adams, Nigel J. Pyne, Pyne, Susan, Adams, David R., Pyne, Nigel J. |
| Abstract |
There is substantial evidence that the enzymes, sphingosine kinase 1 and 2, which catalyse the formation of the bioactive lipid sphingosine 1-phosphate, are involved in pathophysiological processes. In this chapter, we appraise the evidence that both enzymes are druggable and describe how isoform-specific inhibitors can be developed based on the plasticity of the sphingosine-binding site. This is contextualised with the effect of sphingosine kinase inhibitors in cancer, pulmonary hypertension, neurodegeneration, inflammation and sickling. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 10 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Unspecified | 1 | 10% |
| Professor | 1 | 10% |
| Student > Bachelor | 1 | 10% |
| Researcher | 1 | 10% |
| Unknown | 6 | 60% |
| Readers by discipline | Count | As % |
|---|---|---|
| Unspecified | 1 | 10% |
| Agricultural and Biological Sciences | 1 | 10% |
| Neuroscience | 1 | 10% |
| Chemistry | 1 | 10% |
| Unknown | 6 | 60% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2018.
All research outputs
#15,504,780
of 23,041,514 outputs
Outputs from Handbook of experimental pharmacology
#398
of 647 outputs
Outputs of similar age
#211,428
of 331,052 outputs
Outputs of similar age from Handbook of experimental pharmacology
#1
of 1 outputs
Altmetric has tracked 23,041,514 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 647 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.4. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,052 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them