Chapter title |
Schwann Cell and Axon: An Interlaced Unit—From Action Potential to Phenotype Expression
|
---|---|
Chapter number | 9 |
Book title |
Glial Cells in Health and Disease of the CNS
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-40764-7_9 |
Pubmed ID | |
Book ISBNs |
978-3-31-940762-3, 978-3-31-940764-7
|
Authors |
Felipe A. Court, Jaime Alvarez, Court, Felipe A., Alvarez, Jaime |
Abstract |
Here we propose a model of a peripheral axon with a great deal of autonomy from its cell body-the autonomous axon-but with a substantial dependence on its ensheathing Schwann cell (SC), the axon-SC unit. We review evidence in several fields and show that (i) axons can extend sprouts and grow without the concurrence of the cell body, but regulated by SCs; (ii) axons synthesize their proteins assisted by SCs that supply them with ribosomes and, probably, with mRNAs by way of exosomes; (iii) the molecular organization of the axoplasm, i.e., its phenotype, is regulated by the SC, as illustrated by the axonal microtubular content, which is down-regulated by the SC; and (iv) the axon has a program for self-destruction that is boosted by the SC. The main novelty of this model axon-SC unit is that it breaks with the notion that all proteins of the nerve cell are specified by its own nucleus. The notion of a collaborative specification of the axoplasm by more than one nucleus, which we present here, opens a new dimension in the understanding of the nervous system in health and disease and is also a frame of reference to understand other tissues or cell associations. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 6% |
Unknown | 32 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 24% |
Student > Master | 4 | 12% |
Researcher | 3 | 9% |
Student > Doctoral Student | 2 | 6% |
Student > Bachelor | 2 | 6% |
Other | 4 | 12% |
Unknown | 11 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 18% |
Medicine and Dentistry | 5 | 15% |
Agricultural and Biological Sciences | 4 | 12% |
Neuroscience | 3 | 9% |
Nursing and Health Professions | 1 | 3% |
Other | 4 | 12% |
Unknown | 11 | 32% |