Chapter title |
Clinical Effects, Exhaled Breath Condensate pH and Exhaled Nitric Oxide in Humans After Ethyl Acrylate Exposure
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Chapter number | 242 |
Book title |
Allergy and Respiration
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Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/5584_2016_242 |
Pubmed ID | |
Book ISBNs |
978-3-31-942003-5, 978-3-31-942004-2
|
Authors |
F. Hoffmeyer, J. Bünger, C. Monsé, H. Berresheim, B. Jettkant, A. Beine, T. Brüning, K. Sucker, Hoffmeyer, F., Bünger, J., Monsé, C., Berresheim, H., Jettkant, B., Beine, A., Brüning, T., Sucker, K. |
Abstract |
Ethyl acrylate is an irritant known to affect the upper airways and eyes. An increase of the eye blink frequency in humans was observed during exposure to 5 ppm. Studies on the lower airways are scant and our study objective was the evaluation of pH in exhaled breath condensate (EBC-pH) and nitric oxide in exhaled breath (FeNO) as markers of inflammation. Sixteen healthy volunteers were exposed for 4 h to ethyl acrylate at a concentration of 5 ppm and to sham (0.05 ppm) in an exposure laboratory. Clinical irritation symptoms, EBC-pH (at a pCO2 of 5.33 kPa) and FeNO were assessed before and after exposure. Differences after ethyl acrylate exposure were adjusted for those after sham exposure. 5 ppm ethyl acrylate induced clinical signs of local irritation in the nose and eyes, but not in lower airways. Exposure produced a subtle, but statistically significant, decrease in breathing frequency (1 breath/min; p = 0.017) and a lower EBC-pH (by 0.045 units; p = 0.037). Concerning FeNO, we did not observe significant changes compared to sham exposure. We conclude that local effects induced by 5 ppm ethyl acrylate consist of sensory irritation of eyes and nose. In addition, acute ethyl acrylate exposure to 5 ppm resulted in a net decrease of EBC-pH. Whether that can be interpreted in terms of additional lower airway irritation or already inflammatory alterations set in needs further investigations. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 7 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 43% |
Professor > Associate Professor | 1 | 14% |
Student > Master | 1 | 14% |
Unknown | 2 | 29% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 1 | 14% |
Physics and Astronomy | 1 | 14% |
Neuroscience | 1 | 14% |
Medicine and Dentistry | 1 | 14% |
Unknown | 3 | 43% |