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| Chapter title |
Analyzing the Effect of Aging on CD8+ T-Cell Phenotype Using Flow Cytometry
|
|---|---|
| Chapter number | 10 |
| Book title |
Immunosenescence
|
| Published in |
Methods in molecular biology, January 2015
|
| DOI | 10.1007/978-1-4939-2963-4_10 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-2962-7, 978-1-4939-2963-4
|
| Authors |
Min Sun Shin, Insoo Kang, Shin, Min Sun, Kang, Insoo |
| Abstract |
One of the most noticeable changes in T-cell immunity with aging is the expansion of memory CD8+ T cells, with a decline in naïve phenotype T cells that reflects both diminished thymopoiesis and the effects of chronic antigenic stimulation with age. Flow cytometry is a useful tool in evaluating immune cells including the phenotype characteristics of different T-cell subsets. Here, we show flow cytometric methods measuring the different subsets of human CD8+ T cells that change with aging. |