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Acute Myelogenous Leukemia

Overview of attention for book
Attention for Chapter 2: Epigenetic Mechanisms in AML – A Target for Therapy
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1 tweeter

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31 Mendeley
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Chapter title
Epigenetic Mechanisms in AML – A Target for Therapy
Chapter number 2
Book title
Acute Myelogenous Leukemia
Published in
Cancer treatment and research, August 2009
DOI 10.1007/978-0-387-69259-3_2
Pubmed ID
Book ISBNs
978-0-387-69257-9, 978-0-387-69259-3
Authors

Yasuhiro Oki, Jean - Pierre J. Issa, Oki, Yasuhiro, Issa, Jean - Pierre J.

Abstract

Epigenetics refers to a stable, mitotically perpetuated regulatory mechanism of gene expression without an alteration of the coding sequence. Epigenetic mechanism include DNA methylation and histone tail modifications. Epigenetic regulation is part of physiologic development and becomes abnormal in neoplasia, where silencing of critical genes by DNA methylation or histone deacetylation can contribute to leukemogenesis as an alternative to deletion or loss-of-function mutation. In acute myelogenous leukemia (AML), aberrant DNA methylation can be observed in multiple functionally relevant genes such as p15, p 73, E-cadherin, ID 4, RARbeta2. Abnormal activities of histone tail-modifying enzymes have also been seen in AML, frequently as a direct result of chromosomal translocations. It is now clear that these epigenetic changes play a significant role in development and progression of AML, and thus constitute important targets of therapy. The aim of targeting epigenetic effector protein or "epigenetic therapy" is to reverse epigenetic silencing and reactive various genes to induce a therapeutic effect such as differentiation, growth arrest, or apoptosis. Recent clinical studies have shown the relative safety and efficacy of such epigenetic therapies.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 35%
Student > Master 5 16%
Student > Bachelor 5 16%
Student > Postgraduate 2 6%
Researcher 2 6%
Other 5 16%
Unknown 1 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 42%
Medicine and Dentistry 6 19%
Biochemistry, Genetics and Molecular Biology 5 16%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Immunology and Microbiology 1 3%
Other 1 3%
Unknown 4 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2014.
All research outputs
#2,300,568
of 4,507,509 outputs
Outputs from Cancer treatment and research
#28
of 60 outputs
Outputs of similar age
#58,210
of 121,345 outputs
Outputs of similar age from Cancer treatment and research
#10
of 16 outputs
Altmetric has tracked 4,507,509 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 60 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 121,345 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.