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A Modern Approach to Biofilm-Related Orthopaedic Implant Infections

Overview of attention for book
Attention for Chapter 157: Animal Models of Implant-Related Low-Grade Infections. A Twenty-Year Review
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Chapter title
Animal Models of Implant-Related Low-Grade Infections. A Twenty-Year Review
Chapter number 157
Book title
A Modern Approach to Biofilm-Related Orthopaedic Implant Infections
Published in
Advances in experimental medicine and biology, January 2016
DOI 10.1007/5584_2016_157
Pubmed ID
Book ISBNs
978-3-31-952273-9, 978-3-31-952274-6
Authors

Arianna Barbara Lovati, Marta Bottagisio, Elena de Vecchi, Enrico Gallazzi, Lorenzo Drago

Abstract

The demand for joint replacement and surgical treatment is continuously increasing, thus representing a clinical burden and a cost for the healthcare system. Among several pathogens involved in implant-related infections, staphylococci account for the two-thirds of clinically isolated bacteria. Despite most of them are highly virulent microorganisms (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa), low virulent bacteria (Staphylococcus epidermidis, Propionibacterium acnes) are responsible for delayed, low-grade infections without specific clinical signs and hardly distinguishable from aseptic prosthetic failure. Therefore, there is a real need to study the pathogenesis of orthopedic infections through in vivo animal models. The present review of the literature provides a 20-year overview of animal models of acute, subclinical or chronic orthopedic infections according to the pathogen virulence and inocula. Through this analysis, a great variety of conditions in terms of bacterial strains and inocula emerged, thus encouraging the development of more reproducible in vivo studies to provide relevant information for a translational approach to humans.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 23%
Student > Ph. D. Student 7 20%
Student > Doctoral Student 3 9%
Student > Master 3 9%
Student > Postgraduate 2 6%
Other 3 9%
Unknown 9 26%
Readers by discipline Count As %
Medicine and Dentistry 15 43%
Immunology and Microbiology 3 9%
Agricultural and Biological Sciences 2 6%
Engineering 2 6%
Neuroscience 1 3%
Other 1 3%
Unknown 11 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2017.
All research outputs
#10,427,454
of 11,761,635 outputs
Outputs from Advances in experimental medicine and biology
#2,253
of 3,121 outputs
Outputs of similar age
#223,872
of 264,940 outputs
Outputs of similar age from Advances in experimental medicine and biology
#2
of 3 outputs
Altmetric has tracked 11,761,635 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,121 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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