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Mendeley readers
| Chapter title |
Generation and Characterization of Smad7 Conditional Knockout Mice
|
|---|---|
| Chapter number | 14 |
| Book title |
TGF-β Signaling
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-2966-5_14 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-2965-8, 978-1-4939-2966-5
|
| Authors |
Yi Pan, Yan Chen, Pan, Yi, Chen, Yan |
| Abstract |
Smad7 is an important negative modulator that regulates the duration and strength of TGF-β signaling. Dysregulation of Smad7 is associated with the pathogenesis of many human diseases. Various mouse models are developed to facilitate addressing the physiological functions of Smad7. We have recently demonstrated that loss of Smad7 function by deletion in its MH2 domain leads to multiple cardiac defects and aggravates ethanol-induced liver injury. Here, we describe the procedure to construct and characterize the Smad7 conditional knockout mice. |
Mendeley readers
The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 5 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 2 | 40% |
| Professor | 1 | 20% |
| Student > Bachelor | 1 | 20% |
| Student > Ph. D. Student | 1 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 60% |
| Biochemistry, Genetics and Molecular Biology | 2 | 40% |