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TGF-β Signaling

Overview of attention for book
Cover of 'TGF-β Signaling'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Regulation of TGF-β Receptors
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    Chapter 2 Determining TGF-β Receptor Levels in the Cell Membrane.
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    Chapter 3 Posttranslational Modifications of TGF-β Receptors.
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    Chapter 4 Production, Isolation, and Structural Analysis of Ligands and Receptors of the TGF-β Superfamily
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    Chapter 5 Phosphorylation of Smads by Intracellular Kinases
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    Chapter 6 Analysis of Smad Phosphatase Activity In Vitro
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    Chapter 7 Three-dimensional Mammary Epithelial Cell Morphogenesis Model for Analysis of TGFß Signaling.
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    Chapter 8 TGF-β Signaling in Stem Cell Regulation.
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    Chapter 9 Analysis of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor β.
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    Chapter 10 In Vitro Th Differentiation Protocol.
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    Chapter 11 Interrogating TGF-β Function and Regulation in Endothelial Cells.
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    Chapter 12 Isolation and Manipulation of Adipogenic Cells to Assess TGF-β Superfamily Functions.
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    Chapter 13 Imaging TGFβ Signaling in Mouse Models of Cancer Metastasis.
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    Chapter 14 Generation and Characterization of Smad7 Conditional Knockout Mice
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    Chapter 15 Monitoring Smad Activity In Vivo Using the Xenopus Model System.
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    Chapter 16 Animal Cap Assay for TGF-β Signaling.
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    Chapter 17 Detection of Smad Signaling in Zebrafish Embryos.
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    Chapter 18 Role of TGF-β Signaling in Coupling Bone Remodeling
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    Chapter 19 Studying the Functions of TGF-β Signaling in the Ovary.
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    Chapter 20 Quantitative Real-Time PCR Analysis of MicroRNAs and Their Precursors Regulated by TGF-β Signaling.
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    Chapter 21 TGF-β-Regulated MicroRNAs and Their Function in Cancer Biology.
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    Chapter 22 Epigenomic Regulation of Smad1 Signaling During Cellular Senescence Induced by Ras Activation.
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    Chapter 23 The Role of Ubiquitination to Determine Non-Smad Signaling Responses
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    Chapter 24 Genome-Wide RNAi Screening to Dissect the TGF-β Signal Transduction Pathway.
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    Chapter 25 TGF-β Signaling
Attention for Chapter 19: Studying the Functions of TGF-β Signaling in the Ovary.
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Chapter title
Studying the Functions of TGF-β Signaling in the Ovary.
Chapter number 19
Book title
TGF-β Signaling
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-2966-5_19
Pubmed ID
Book ISBNs
978-1-4939-2965-8, 978-1-4939-2966-5
Authors

Yu, Chao, Zhou, Jian-Jie, Fan, Heng-Yu, Chao Yu, Jian-Jie Zhou, Heng-Yu Fan

Abstract

In mammals, ovulation is a multistep physiological process that includes preovulatory follicle growth, oocyte meiotic maturation, cumulus-oocyte complex (COC) expansion, follicle rupture, and luteinization. TGF-β signaling pathway has multiple functions in mammalian ovary, as its complexity in ovarian function has been demonstrated by mouse models with knockouts of TGF-β receptors and SMADs. We describe the protocol that we use to study functions of TGF-β signaling pathway in follicle development and ovulation. Because total knockout of TGF-β pathway components often causes embryonic lethality, which prevents further investigation of these genes in ovarian functions, people have generated ovarian cell type-specific knockout mouse strains for TGF-β signaling pathway genes. These mouse models are also described.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 33%
Student > Master 2 33%
Unknown 2 33%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 33%
Biochemistry, Genetics and Molecular Biology 1 17%
Immunology and Microbiology 1 17%
Unknown 2 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 November 2015.
All research outputs
#14,240,471
of 22,831,537 outputs
Outputs from Methods in molecular biology
#4,191
of 13,126 outputs
Outputs of similar age
#205,980
of 393,555 outputs
Outputs of similar age from Methods in molecular biology
#417
of 1,470 outputs
Altmetric has tracked 22,831,537 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,126 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 393,555 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,470 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.