Chapter title |
Prion Seeded Conversion and Amplification Assays.
|
---|---|
Chapter number | 184 |
Book title |
Prion Proteins
|
Published in |
Topics in current chemistry, June 2011
|
DOI | 10.1007/128_2011_184 |
Pubmed ID | |
Book ISBNs |
978-3-64-224066-9, 978-3-64-224067-6
|
Authors |
Christina D Orrú, Byron Caughey, Christina D. Orrú |
Abstract |
The conversion of the normal prion protein (PrP(C)) into its misfolded, aggregation-prone and infectious (prion) isoform is central to the progression of transmissible spongiform encephalopathies (TSEs) or prion diseases. Since the initial development of a cell free PrP conversion reaction, striking progress has been made in the development of much more continuous prion-induced conversion and amplification reactions. These studies have provided major insights into the molecular underpinnings of prion propagation and enabled the development of ultra-sensitive tests for prions and prion disease diagnosis. This chapter will provide an overview of such reactions and the practical and fundamental consequences of their development. |
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