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Prion Proteins

Overview of attention for book
Attention for Chapter 184: Prion Seeded Conversion and Amplification Assays.
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1 tweeter

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25 Mendeley
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1 CiteULike
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Chapter title
Prion Seeded Conversion and Amplification Assays.
Chapter number 184
Book title
Prion Proteins
Published in
Topics in current chemistry, June 2011
DOI 10.1007/128_2011_184
Pubmed ID
Book ISBNs
978-3-64-224066-9, 978-3-64-224067-6
Authors

Christina D Orrú, Byron Caughey, Christina D. Orrú

Abstract

The conversion of the normal prion protein (PrP(C)) into its misfolded, aggregation-prone and infectious (prion) isoform is central to the progression of transmissible spongiform encephalopathies (TSEs) or prion diseases. Since the initial development of a cell free PrP conversion reaction, striking progress has been made in the development of much more continuous prion-induced conversion and amplification reactions. These studies have provided major insights into the molecular underpinnings of prion propagation and enabled the development of ultra-sensitive tests for prions and prion disease diagnosis. This chapter will provide an overview of such reactions and the practical and fundamental consequences of their development.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
Hungary 1 4%
France 1 4%
Unknown 22 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 36%
Researcher 8 32%
Student > Bachelor 4 16%
Professor > Associate Professor 2 8%
Professor 1 4%
Other 0 0%
Unknown 1 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 40%
Biochemistry, Genetics and Molecular Biology 9 36%
Medicine and Dentistry 2 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Immunology and Microbiology 1 4%
Other 1 4%
Unknown 1 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2011.
All research outputs
#3,111,332
of 4,506,051 outputs
Outputs from Topics in current chemistry
#30
of 65 outputs
Outputs of similar age
#2,399,413
of 3,441,625 outputs
Outputs of similar age from Topics in current chemistry
#25
of 58 outputs
Altmetric has tracked 4,506,051 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 65 research outputs from this source. They receive a mean Attention Score of 1.5. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 3,441,625 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.