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Prion Proteins

Overview of attention for book
Attention for Chapter 190: The PrP-Like Proteins Shadoo and Doppel.
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34 Mendeley
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Chapter title
The PrP-Like Proteins Shadoo and Doppel.
Chapter number 190
Book title
Prion Proteins
Published in
Topics in current chemistry, July 2011
DOI 10.1007/128_2011_190
Pubmed ID
Book ISBNs
978-3-64-224066-9, 978-3-64-224067-6
Authors

David Westaway, Nathalie Daude, Serene Wohlgemuth, Paul Harrison

Abstract

An almost unique place within protein databases, twenty-five years of study has underscored the enigmatically subtle role of PrP(C) in normal cell biology. It seems that PrP has evolved (and survived) to perform a function that does not have a precedent amongst transmembrane cell-surface proteins, perhaps representing a new type of plasma membrane ecosystem. In a context where we await a clarifying insight to unify a panoply of PrP(C) data into logical molecular framework, the GPI-anchored N-glycosylated Doppel and Sho proteins are tantalizing in that they correspond roughly to the front and back halves of PrP(C) itself. These molecules may be simpler - and more "understandable" - entities that can be pursued in parallel to PrP(C), and could open up the biology of mammalian prion proteins from fresh directions. Dpl has a profound role in successful gametogenesis that warrants close scrutiny and a case for deeper study can be made for Sho, a recently discovered CNS-expressed protein with many parallels to established facets of PrP biochemistry. In an aerial view of biomedical research, Sho and Dpl can be considered as adjacent islands in a prion protein archipelago. As such, the coming years of molecular exploration should be extremely interesting.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hungary 1 3%
Portugal 1 3%
France 1 3%
Canada 1 3%
Unknown 30 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 47%
Researcher 9 26%
Professor 3 9%
Student > Bachelor 2 6%
Student > Master 2 6%
Other 2 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 56%
Biochemistry, Genetics and Molecular Biology 9 26%
Neuroscience 3 9%
Immunology and Microbiology 1 3%
Medicine and Dentistry 1 3%
Other 1 3%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2011.
All research outputs
#3,094,755
of 4,506,935 outputs
Outputs from Topics in current chemistry
#30
of 65 outputs
Outputs of similar age
#2,396,866
of 3,442,079 outputs
Outputs of similar age from Topics in current chemistry
#25
of 58 outputs
Altmetric has tracked 4,506,935 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 65 research outputs from this source. They receive a mean Attention Score of 1.5. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 3,442,079 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.