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Prion Proteins

Overview of attention for book
Cover of 'Prion Proteins'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 157 Genetics of Prion Disease
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    Chapter 158 Molecular Dynamics as an Approach to Study Prion Protein Misfolding and the Effect of Pathogenic Mutations
  4. Altmetric Badge
    Chapter 159 Chronic Wasting Disease
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    Chapter 160 Neuroprotective and Neurotoxic Signaling by the Prion Protein
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    Chapter 161 Atypical Prion Diseases in Humans and Animals
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    Chapter 165 Prion Protein and Its Conformational Conversion: A Structural Perspective
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    Chapter 166 Transgenic Mouse Models and Prion Strains.
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    Chapter 172 Prion Proteins
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    Chapter 184 Prion Seeded Conversion and Amplification Assays.
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    Chapter 190 The PrP-Like Proteins Shadoo and Doppel.
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    Chapter 201 Chemical Biology of Prion Protein: Tools to Bridge the In Vitro/Vivo Interface.
Attention for Chapter 201: Chemical Biology of Prion Protein: Tools to Bridge the In Vitro/Vivo Interface.
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Chapter title
Chemical Biology of Prion Protein: Tools to Bridge the In Vitro/Vivo Interface.
Chapter number 201
Book title
Prion Proteins
Published in
Topics in current chemistry, July 2011
DOI 10.1007/128_2011_201
Pubmed ID
21769714
Book ISBNs
978-3-64-224066-9, 978-3-64-224067-6
Authors

Ralf Seidel, Martin Engelhard

Abstract

Research on prion protein (PrP) and pathogenic prion has been very intensive because of its importance as model system for neurodegenerative diseases. One important aspect of this research has been the application of chemical biology tools. In this review we describe new developments like native chemical ligation (NCL) and expressed protein ligation (EPL) for the synthesis and semisynthesis of proteins in general and PrP in particular. These techniques allow the synthesis of designed tailor made analogs which can be used in conjunction with modern biophysical methods like fluorescence spectroscopy, solid state Nuclear Magnetic Resonance (ssNMR), and Electron Paramagnetic Resonance (EPR). Another aspect of prion research is concerned with the interaction of PrP with small organic molecules and metals. The results are critically reviewed and put into perspective of their implication for PrP function.

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Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 48%
Researcher 5 24%
Professor 3 14%
Student > Master 2 10%
Professor > Associate Professor 1 5%
Other 0 0%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 38%
Biochemistry, Genetics and Molecular Biology 7 33%
Chemistry 2 10%
Immunology and Microbiology 2 10%
Business, Management and Accounting 1 5%
Other 0 0%
Unknown 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2011.
All research outputs
#3,094,893
of 4,506,935 outputs
Outputs from Topics in current chemistry
#30
of 65 outputs
Outputs of similar age
#38,214
of 56,810 outputs
Outputs of similar age from Topics in current chemistry
#1
of 5 outputs
Altmetric has tracked 4,506,935 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 65 research outputs from this source. They receive a mean Attention Score of 1.5. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 56,810 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them

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