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Pulmonary Dysfunction and Disease

Overview of attention for book
Attention for Chapter 18: Heart Rate Variability and Arrhythmic Burden in Pulmonary Hypertension
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1 tweeter

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Chapter title
Heart Rate Variability and Arrhythmic Burden in Pulmonary Hypertension
Chapter number 18
Book title
Pulmonary Dysfunction and Disease
Published in
Advances in experimental medicine and biology, May 2016
DOI 10.1007/5584_2016_18
Pubmed ID
Book ISBNs
978-3-31-942009-7, 978-3-31-942010-3
Authors

Witte, C, Meyer Zur Heide Genannt Meyer-Arend, J U, Andrié, R, Schrickel, J W, Hammerstingl, C, Schwab, J O, Nickenig, G, Skowasch, D, Pizarro, Carmen, C. Witte, J. U. Meyer zur Heide genannt Meyer-Arend, R. Andrié, J. W. Schrickel, C. Hammerstingl, J. O. Schwab, G. Nickenig, D. Skowasch, C. Pizarro

Abstract

A growing body of evidence indicates that sudden cardiac death constitutes a major cause of mortality in pulmonary hypertension (PH). As validated method to evaluate cardiac autonomic system dysfunction, alterations in heart rate variability (HRV) are predictive of arrhythmic events, particularly in left ventricular disease. Here, we sought to determine the clinical value of HRV assessment in PH. Sixty-four patients were allocated to different PH-subgroups in this prospectively conducted trial: 25 patients with pulmonary arterial hypertension (PAH), 11 patients with chronic thromboembolic PH (CTEPH), and 28 patients with COPD-induced PH. All patients underwent 24-h Holter electrocardiogram for HRV assessment by time- and frequency-domain analysis. Arrhythmic burden was evaluated by manual analysis and complementary automatic measurement of premature atrial and ventricular contractions. The results were compared to 31 healthy controls. The PAH patients offered a significantly higher mean heart rate (78.6 ± 10.4 bpm vs. 70.1 ± 10.3 bpm, p = 0.04), a higher burden of premature ventricular contractions (p < 0.01), and decreases in HRV (SDNN: p < 0.01; SDANN: p < 0.01; very low frequency: p < 0.01; low frequency/high frequency ratio: p < 0.01; total power: p = 0.02). In CTEPH patients, only the amount of premature ventricular contractions differed from controls (p < 0.01), whereas in COPD both premature atrial contraction count and frequency-domain-based HRV manifested significant differences. In conclusion, PAH appears to be primarily affected by HRV alterations and ventricular arrhythmic burden, indicating a high risk for malignant arrhythmic events.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 22%
Student > Postgraduate 4 15%
Student > Ph. D. Student 4 15%
Student > Master 3 11%
Other 2 7%
Other 5 19%
Unknown 3 11%
Readers by discipline Count As %
Medicine and Dentistry 16 59%
Biochemistry, Genetics and Molecular Biology 1 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Arts and Humanities 1 4%
Engineering 1 4%
Other 0 0%
Unknown 7 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2016.
All research outputs
#11,726,776
of 13,209,548 outputs
Outputs from Advances in experimental medicine and biology
#2,414
of 3,241 outputs
Outputs of similar age
#221,695
of 266,077 outputs
Outputs of similar age from Advances in experimental medicine and biology
#20
of 30 outputs
Altmetric has tracked 13,209,548 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,241 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.