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Circular RNAs function as ceRNAs to regulate and control human cancer progression

Overview of attention for article published in Molecular Cancer, April 2018
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Mentioned by

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2 tweeters

Citations

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245 Dimensions

Readers on

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65 Mendeley
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Title
Circular RNAs function as ceRNAs to regulate and control human cancer progression
Published in
Molecular Cancer, April 2018
DOI 10.1186/s12943-018-0827-8
Pubmed ID
Authors

Yaxian Zhong, Yajun Du, Xue Yang, Yongzhen Mo, Chunmei Fan, Fang Xiong, Daixi Ren, Xin Ye, Chunwei Li, Yumin Wang, Fang Wei, Can Guo, Xu Wu, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong

Abstract

Circular RNAs (circRNAs) are connected at the 3' and 5' ends by exon or intron cyclization, forming a complete ring structure. circRNA is more stable and conservative than linear RNA and abounds in various organisms. In recent years, increasing numbers of reports have found that circRNA plays a major role in the biological functions of a network of competing endogenous RNA (ceRNA). circRNAs can compete together with microRNAs (miRNAs) to influence the stability of target RNAs or their translation, thus, regulating gene expression at the transcriptional level. circRNAs are involved in biological processes such as tumor cell proliferation, apoptosis, invasion, and migration as ceRNAs. circRNAs, therefore, represent promising candidates for clinical diagnosis and treatment. Here, we review the progress in studying the role of circRNAs as ceRNAs in tumors and highlight the participation of circRNAs in signal transduction pathways to regulate cellular functions.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 65 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 22%
Student > Ph. D. Student 12 18%
Student > Bachelor 8 12%
Researcher 7 11%
Student > Postgraduate 4 6%
Other 6 9%
Unknown 14 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 22 34%
Medicine and Dentistry 9 14%
Agricultural and Biological Sciences 5 8%
Neuroscience 3 5%
Immunology and Microbiology 3 5%
Other 4 6%
Unknown 19 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2018.
All research outputs
#8,643,678
of 13,858,019 outputs
Outputs from Molecular Cancer
#618
of 1,176 outputs
Outputs of similar age
#164,139
of 276,071 outputs
Outputs of similar age from Molecular Cancer
#1
of 1 outputs
Altmetric has tracked 13,858,019 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,176 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,071 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them