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Therapeutic Applications of Ribozymes and Riboswitches

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Cover of 'Therapeutic Applications of Ribozymes and Riboswitches'

Table of Contents

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    Book Overview
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    Chapter 1 Identification of regulatory RNA in bacterial genomes by genome-scale mapping of transcription start sites.
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    Chapter 2 Screening Inhibitory Potential of Anti-HIV RT RNA Aptamers
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    Chapter 3 Design and Evaluation of Clinically Relevant SOFA-HDV Ribozymes Targeting HIV RNA
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    Chapter 4 Directing RNase P-Mediated Cleavage of Target mRNAs by Engineered External Guide Sequences in Cultured Cells
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    Chapter 5 Design and Analysis of Hammerhead Ribozyme Activity Against an Artificial Gene Target
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    Chapter 6 Knockdown Strategies for the Study of Proprotein Convertases and Proliferation in Prostate Cancer Cells
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    Chapter 7 Use of Tumor-Targeting Trans -Splicing Ribozyme for Cancer Treatment
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    Chapter 8 Characterization of Hairpin Ribozyme Reactions
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    Chapter 9 Finding Instances of Riboswitches and Ribozymes by Homology Search of Structured RNA with Infernal
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    Chapter 10 Structure-Based Virtual Screening for the Identification of RNA-Binding Ligands
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    Chapter 11 Probing Riboswitch Binding Sites with Molecular Docking, Focused Libraries, and In-line Probing Assays
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    Chapter 12 Discovery of Small Molecule Modifiers of microRNAs for the Treatment of HCV Infection
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    Chapter 13 Bacterial Flavin Mononucleotide Riboswitches as Targets for Flavin Analogs
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    Chapter 14 Construction and Application of Riboswitch-Based Sensors That Detect Metabolites Within Bacterial Cells
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    Chapter 15 Screening Assays to Identify Artificial glmS Ribozyme Activators
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    Chapter 16 Analysis of Riboswitch Structure and Ligand Binding Using Small-Angle X-ray Scattering (SAXS)
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    Chapter 17 Use of SHAPE to Select 2AP Substitution Sites for RNA–Ligand Interactions and Dynamics Studies
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    Chapter 18 Cell Internalization SELEX: In Vitro Selection for Molecules That Internalize into Cells
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    Chapter 19 Therapeutic Applications of Ribozymes and Riboswitches
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