Gene Therapy for Neurological Disorders

Table of Contents

1. Altmetric Badge
   Book Overview
2. Altmetric Badge
   Chapter 1 Introduction to Viral Vectors and Other Delivery Methods for Gene Therapy of the Nervous System
3. Altmetric Badge
   Chapter 2 Delivering Transgenic DNA Exceeding the Carrying Capacity of AAV Vectors
4. Altmetric Badge
   Chapter 3 Expression of Multiple Functional RNAs or Proteins from One Viral Vector.
5. Altmetric Badge
   Chapter 4 Regulated Gene Therapy
6. Altmetric Badge
   Chapter 5 Design of shRNA and miRNA for Delivery to the CNS.
7. Altmetric Badge
   Chapter 6 Tissue-Specific Promoters in the CNS
8. Altmetric Badge
   Chapter 7 Small-Scale Recombinant Adeno-Associated Virus Purification.
9. Altmetric Badge
   Chapter 8 Lentivirus Production and Purification
10. Altmetric Badge
    Chapter 9 Viral Vector Production: Adenovirus.
11. Altmetric Badge
    Chapter 10 Controlling AAV Tropism in the Nervous System with Natural and Engineered Capsids
12. Altmetric Badge
    Chapter 11 Altering Tropism of rAAV by Directed Evolution
13. Altmetric Badge
    Chapter 12 Altering Entry Site Preference of Lentiviral Vectors into Neuronal Cells by Pseudotyping with Envelope Glycoproteins.
14. Altmetric Badge
    Chapter 13 Directed Evolution of Adenoviruses
15. Altmetric Badge
    Chapter 14 Intraparenchymal Stereotaxic Delivery of rAAV and Special Considerations in Vector Handling
16. Altmetric Badge
    Chapter 15 MRI-Guided Delivery of Viral Vectors
17. Altmetric Badge
    Chapter 16 Systemic Gene Therapy for Targeting the CNS
18. Altmetric Badge
    Chapter 17 Widespread Neuronal Transduction of the Rodent CNS via Neonatal Viral Injection.
19. Altmetric Badge
    Chapter 18 AAV-Mediated Gene Transfer to Dorsal Root Ganglion
20. Altmetric Badge
    Chapter 19 Gene Therapy of the Peripheral Nervous System: The Enteric Nervous System
21. Altmetric Badge
    Chapter 20 Gene Therapy of the Peripheral Nervous System: Celiac Ganglia
22. Altmetric Badge
    Chapter 21 Convection Enhanced Delivery of Recombinant Adeno-associated Virus into the Mouse Brain
23. Altmetric Badge
    Chapter 22 Nonviral Gene Therapy of the Nervous System: Electroporation
24. Altmetric Badge
    Chapter 23 Non-Viral, Lipid-Mediated DNA and mRNA Gene Therapy of the Central Nervous System (CNS): Chemical-Based Transfection
25. Altmetric Badge
    Chapter 24 Ex Vivo Gene Therapy Using Human Mesenchymal Stem Cells to Deliver Growth Factors in the Skeletal Muscle of a Familial ALS Rat Model.
26. Altmetric Badge
    Chapter 25 Gene Therapy Models of Alzheimer's Disease and Other Dementias.
27. Altmetric Badge
    Chapter 26 Viral Vector-Based Modeling of Neurodegenerative Disorders: Parkinson's Disease.
28. Altmetric Badge
    Chapter 27 Gene Therapy-Based Modeling of Neurodegenerative Disorders: Huntington's Disease.
29. Altmetric Badge
    Chapter 28 Gene Therapy for the Treatment of Neurological Disorders: Amyotrophic Lateral Sclerosis.
30. Altmetric Badge
    Chapter 29 Stereotaxic Surgical Targeting of the Nonhuman Primate Caudate and Putamen: Gene Therapy for Huntington's Disease.
31. Altmetric Badge
    Chapter 30 Gene Therapy for the Treatment of Neurological Disorders: Metabolic Disorders
32. Altmetric Badge
    Chapter 31 Gene Therapy for the Treatment of Neurological Disorders: Central Nervous System Neoplasms
33. Altmetric Badge
    Chapter 32 AAV2-Neurturin for Parkinson’s Disease: What Lessons Have We Learned?