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Molecular Biology and Pathogenesis of Coronaviruses

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Cover of 'Molecular Biology and Pathogenesis of Coronaviruses'

Table of Contents

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    Book Overview
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    Chapter 1 Biochemistry of Coronaviruses 1983
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    Chapter 2 Organization of the IBV Genome
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    Chapter 3 Proteolytic Cleavage of Peplomeric Glycoprotein E2 of MHV Yields Two 90K Subunits and Activates Cell Fusion
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    Chapter 4 Coronavirus Maturation
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    Chapter 5 In Vitro Assembly of the Murine Coronavirus Membrane Protein E1
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    Chapter 6 Characterization of Viral Proteins Synthesized in 229E Infected Cells and Effect(s) of Inhibition of Glycosylation and Glycoprotein Transport
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    Chapter 7 Defective Replication of Porcine Transmissible Gastroenteritis Virus in a Continuous Cell Line
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    Chapter 8 Structural Characterization of IBV Glycoproteins
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    Chapter 9 Use of Monoclonal Antibodies to Assess Antigenic Relationships of Avian Infectious Bronchitis Virus Serotypes in the United States
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    Chapter 10 Monoclonal Antibodies to the Three Classes of Mouse Hepatitis Virus Strain A59 Proteins
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    Chapter 11 Antigenic and Polypeptide Structure of Bovine Enteric Coronavirus as Defined by Monoclonal Antibodies
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    Chapter 12 Plaque Assay, Polypeptide Composition and Immunochemistry of Feline Infectious Peritonitis Virus and Feline Enteric Coronavirus Isolates
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    Chapter 13 Assembly of 229E Virions in Human Embryonic Lung Fibroblasts and Effects of Inhibition of Glycosylation and Glycoprotein Transport on this Process
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    Chapter 14 Amphotericin Inhibits Coronavirus SD, SK and A59 Growth
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    Chapter 15 Electron Lucent Structures Induced by Coronaviruses
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    Chapter 16 Cloning and Sequencing the Nucleocapsid and E1 Genes of Coronavirus
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    Chapter 17 Nucleotide sequencing of mouse hepatitis virus strain JHM messenger RNA 7.
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    Chapter 18 Transcription strategy of coronaviruses: fusion of non-contiguous sequences during mRNA synthesis.
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    Chapter 19 Studies on the Mechanism of RNA Synthesis of a Murine Coronavirus
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    Chapter 20 Glycoprotein E1 of MHV-A59: Structure of the 0-Linked Carbohydrates and Construction of Full Length Recombinant cDNA Clones
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    Chapter 21 DNA Sequencing Studies of Genomic cDNA Clones of Avian Infectious Bronchitis Virus
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    Chapter 22 The Genome of Transmissible Gastroenteritis Virus (TGEV)
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    Chapter 23 Biology of Coronaviruses 1983
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    Chapter 24 MHV-A59 Pathogenesis in Mice
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    Chapter 25 Detection of MHV-A59 RNA by In Situ Hybridization
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    Chapter 26 Virological and Immunological Aspects of Coronavirus Induced Subacute Demyelinating Encephalomyelitis in Rats
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    Chapter 27 A One Year Study of Coronavirus SD Infection in Mice
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    Chapter 28 Immunosuppression with Cyclophosphamide Does Not Prevent Demyelination or Result in Uncontrolled Viral Replication in Coronavirus SD Infected Mice
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    Chapter 29 In Vivo and In Vitro Models of Demyelinating Diseases — VIII: Genetic, Immunologic and Cellular Influences on JHM Virus Infection of Rats
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    Chapter 30 Restricted Replication of a Temperature Sensitive Mutant of MHV-A59 in Mouse Brain Astrocytes
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    Chapter 31 Replication of Murine Coronaviruses in Somatic Cell Hybrids Formed Between a Mouse Fibroblast Cell Line and Either a Rat Schwannoma Line or a Rat Glioma Line
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    Chapter 32 Persistent In Vitro Infection with Mouse Hepatitis Virus 3
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    Chapter 33 Characterization of MHV-A59 Persistently Infected Cells
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    Chapter 34 Fine Specificity and Genetic Restriction of T Cell Clones Specific for Mouse Hepatitis Virus, Strain JHM
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    Chapter 35 The immune response to mouse hepatitis virus: genetic variation in antibody response and disease.
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    Chapter 36 Pathogenic Differences Between Various Feline Coronavirus Isolates
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    Chapter 37 Expression of Feline Infectious Peritonitis (FIP) Coronavirus Antigens on the Surface of Feline Macrophage-Like Cells
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    Chapter 38 Role of Circulating Antibodies and Thymus-Dependent Lymphocytes in Production of Effusive Type Feline Infectious Peritonitis After Oral Infection
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    Chapter 39 Interactions of Porcine Enteric Coronavirus TGEV with Macrophages and Lymphocytes
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    Chapter 40 Effect of Stomach and Gut Juices on Infectivity of Low and High Passaged Strains of T.G.E. Coronavirus: Properties of a Virus Mutant Resistant to Inactivation by Stomach Juice Obtained by Cycles of Survivor Selection in Tissue Culture
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    Chapter 41 Pathogenicity of Mouse Hepatitis Virus, MHV-2cc, From a Persistently Infected DBT Cell Line
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    Chapter 42 The Pathogenesis and Age Related Susceptibility of OC43 Virus in Mice
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    Chapter 43 Failure to Detect Coronavirus SK Antigen in Multiple Sclerosis Brain Tissue by Autoradiography
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    Chapter 44 Antiviral Action of Interferon in the Bovine Species: Study In Vitro and In Vivo
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    Chapter 45 The Effects of Mouse Hepatitis Virus Type 3 on the Microcirculation of the Liver in Inbred Strains of Mice
Attention for Chapter 18: Transcription strategy of coronaviruses: fusion of non-contiguous sequences during mRNA synthesis.
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Chapter title
Transcription strategy of coronaviruses: fusion of non-contiguous sequences during mRNA synthesis.
Chapter number 18
Book title
Molecular Biology and Pathogenesis of Coronaviruses
Published in
Advances in experimental medicine and biology, January 1984
DOI 10.1007/978-1-4615-9373-7_18
Pubmed ID
Book ISBNs
978-1-4615-9375-1, 978-1-4615-9373-7
Authors

Willy Spaan, Hajo Delius, Mike A. Skinner, John Armstrong, Pete Rottier, Sjef Smeekens, Stuart G. Siddell, Bernard van der Zeijst, Spaan, Willy, Delius, Hajo, Skinner, Mike A., Armstrong, John, Rottier, Pete, Smeekens, Sjef, Siddell, Stuart G., van der Zeijst, Bernard

Abstract

MHV replicates in the cell cytoplasm and viral genetic information is expressed in infected cells as one genomic sized RNA ( mRNA1 ) and six subgenomic mRNAs. The seven RNAs were assumed to have common 3' ends of the size of RNA7 , the smallest RNA. The data reported here, show that this model is too simple and that the mRNAs are composed of a leader and body sequence. Electron microscopic analysis of hybrids formed between single stranded cDNA copied from mRNA7 and genomic RNA or mRNA6 shows that genomic RNA, mRNA6 and mRNA7 have common 5' terminal sequences. Furthermore, nucleotide sequence analysis shows that the nucleotide sequence of the 5' end of mRNA7 diverges from the corresponding region of the genome just upstream from the initiation codon of the nucleocapsid gene. Because the synthesis of each mRNA is inactivated by UV irradiation in proportion to its own length, the subgenomic mRNAs are apparently not produced by the processing of larger RNAs. The available data have to be explained by translocation of the polymerase/leader complex to specific internal positions on the negative strand. In this way the leader and body sequences are joined together by a mechanism completely different from conventional RNA splicing but nevertheless giving the same end result.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 33%
Librarian 1 11%
Professor 1 11%
Lecturer 1 11%
Professor > Associate Professor 1 11%
Other 1 11%
Unknown 1 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 33%
Veterinary Science and Veterinary Medicine 1 11%
Immunology and Microbiology 1 11%
Chemistry 1 11%
Engineering 1 11%
Other 0 0%
Unknown 2 22%