| Chapter title |
Molecular Magnetic Resonance Imaging (mMRI)
|
|---|---|
| Chapter number | 19 |
| Book title |
Preclinical MRI
|
| Published in |
Methods in molecular biology, January 2018
|
| DOI | 10.1007/978-1-4939-7531-0_19 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-7530-3, 978-1-4939-7531-0
|
| Authors |
Maxime Gauberti, Antoine P. Fournier, Denis Vivien, Sara Martinez de Lizarrondo, Gauberti, Maxime, Fournier, Antoine P., Vivien, Denis, Martinez de Lizarrondo, Sara |
| Abstract |
Molecular magnetic resonance imaging (mMRI) enables the detection of a protein of interest in vivo, in a noninvasive manner. The general concept of mMRI is to target a contrast agent to a protein of interest, and to perform a contrast-sensitive MRI sequence. Typically, contrast agents are made of a "contrastophore" (the part of the construct responsible for the contrast on the images) and a targeting moiety ("pharmacophore"). Recently, the development of a new family of contrastophore carrying a high payload of iron oxide (micro-sized particles of iron oxide, MPIO) has led to a dramatic increase in the sensitivity of mMRI. Here, we describe the production of targeted MPIO using commercially available reagents and the MRI protocols to allow their detection in vivo. |
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